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US 12,410,317 B2Granted
Engineered skin equivalent, method of manufacture thereof and products derived therefrom
AssigneesFaircraft, King's College London
InventorsIngvar Helgason, Dusko Ilic
Life of this patent
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Abstract
Disclosed herein are synthetic leathers, artificial epidermal layers, artificial dermal layers, layered structures, products produced therefrom and methods of producing the same.
Claims17
A method of forming a tanned synthetic leather, wherein the method comprises:
- culturing a fibroblast on a scaffold;
- and
- tanning a collagenous extracellular matrix comprising collagen secreted by the fibroblast to generate the tanned synthetic leather.
A composition comprising a cell layer comprising a fibroblast in contact with a scaffold and an extracellular matrix, wherein the extracellular matrix comprises a type I collagen, a type III collagen, or a combination thereof, and wherein the composition is suitable for tanning to form a tanned synthetic leather.
Dependencies are inferred from the claim text.