Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations

A pressurized valve container, comprising:

• a container including a valve;
• a pressurized inverse thermosensitive polymer foam formulation stored in the container, the container configured to maintain the formulation under pressure and dispense the formulation upon opening the valve, the formulation comprising:
• an aqueous solution of a copolymer of ethylene oxide and propylene oxide, wherein the aqueous solution is configured to undergo a reverse phase change from a liquid to a gel;
• one or more antibiotics, the one or more antibiotics including vancomycin at a concentration between about 0.1% w/w to about 6.0% w/w;
• a preservative;
• a pH adjuster;
• and
• an expanding component that is a liquified hydrofluorocarbon gas, wherein
• the formulation comprises a stable and macroscopically homogenous solution,
• wherein the container is configured to deploy the formulation such that the liquified hydrofluorocarbon gas causes the formulation to foam after the formulation is dispensed from the container,
• the formulation is configured to be applied topically following deployment from the container,
• and
• the formulation is configured to initially be deployed from the container at a lower viscosity to spread more easily and becomes more viscous upon contact with the body.