US 12,410,241 B2Granted

Human monoclonal antibodies to enterovirus D68

AssigneeVanderbilt University

InventorsJames E. Crowe, Jr., Matthew R. Vogt

Life of this patent

Estimating the term…

Abstract

The present disclosure is directed to human and engineered antibodies and fragments thereof binding to enterovirus D68 (EV-D68), engineered cells producing the same, and of using the antibodies and fragments thereof in methods for both diagnosing and treating EV-D68 infections. Also disclosed are vaccine formulations comprising one of more of the antibody and fragments thereof, as well as vectors encoding the same.

Claims26

Dependent claims

A method of treating a subject infected with enterovirus D68 (EV-D68) or reducing the likelihood of infection of a subject at risk of contracting EV-D68, comprising delivering to said subject an antibody or antibody fragment comprising heavy chain CDR1-3 of SEQ ID NOS:

257, 258 and 259, and light chain CDR1-3 of SEQ ID NOS:
449, 450 and 451;
heavy chain CDR1-3 of SEQ ID NOS:
260, 261 and 262, and light chain CDR1-3 of SEQ ID NOS:
452, 453 and 454;
heavy chain CDR1-3 of SEQ ID NOS:
263, 264 and 265, and light chain CDR1-3 of SEQ ID NOS:
455, 456 and 457;
heavy chain CDR1-3 of SEQ ID NOS:
266, 267 and 268, and light chain CDR1-3 of SEQ ID NOS:
458, 459 and 460;
heavy chain CDR1-3 of SEQ ID NOS:
269, 270 and 271, and light chain CDR1-3 of SEQ ID NOS:
461, 462 and 463;
heavy chain CDR1-3 of SEQ ID NOS:
272, 273 and 274, and light chain CDR1-3 of SEQ ID NOS:
464, 465 and 466;
heavy chain CDR1-3 of SEQ ID NOS:
275, 276 and 277, and light chain CDR1-3 of SEQ ID NOS:
467, 468 and 469;
heavy chain CDR1-3 of SEQ ID NOS:
278, 279 and 280, and light chain CDR1-3 of SEQ ID NOS:
470, 471 and 472;
heavy chain CDR1-3 of SEQ ID NOS:
281, 282 and 283, and light chain CDR1-3 of SEQ ID NOS:
473, 474 and 475;
heavy chain CDR1-3 of SEQ ID NOS:
284, 285 and 286, and light chain CDR1-3 of SEQ ID NOS:
476, 477 and 478;
heavy chain CDR1-3 of SEQ ID NOS:
287, 288 and 289, and light chain CDR1-3 of SEQ ID NOS:
479, 480 and 481;
heavy chain CDR1-3 of SEQ ID NOS:
290, 291 and 292, and light chain CDR1-3 of SEQ ID NOS:
482, 483 and 484;
heavy chain CDR1-3 of SEQ ID NOS:
293, 294 and 295, and light chain CDR1-3 of SEQ ID NOS:
485, 486 and 487;
heavy chain CDR1-3 of SEQ ID NOS:
296, 297 and 298, and light chain CDR1-3 of SEQ ID NOS:
488, 489 and 490;
heavy chain CDR1-3 of SEQ ID NOS:
299, 300 and 301, and light chain CDR1-3 of SEQ ID NOS:
491, 492 and 493;
heavy chain CDR1-3 of SEQ ID NOS:
302, 303 and 304, and light chain CDR1-3 of SEQ ID NOS:
494, 495 and 496;
heavy chain CDR1-3 of SEQ ID NOS:
305, 306 and 307, and light chain CDR1-3 of SEQ ID NOS:
497, 498 and 499;
heavy chain CDR1-3 of SEQ ID NOS:
308, 309 and 310, and light chain CDR1-3 of SEQ ID NOS:
500, 501 and 502;
heavy chain CDR1-3 of SEQ ID NOS:
311, 312 and 313, and light chain CDR1-3 of SEQ ID NOS:
503, 504 and 505;
heavy chain CDR1-3 of SEQ ID NOS:
314, 315 and 316, and light chain CDR1-3 of SEQ ID NOS:
506, 507 and 508;
heavy chain CDR1-3 of SEQ ID NOS:
317, 318 and 319, and light chain CDR1-3 of SEQ ID NOS:
509, 510 and 511;
heavy chain CDR1-3 of SEQ ID NOS:
320, 321 and 322, and light chain CDR1-3 of SEQ ID NOS:
512, 513 and 514;
heavy chain CDR1-3 of SEQ ID NOS:
323, 324 and 325, and light chain CDR1-3 of SEQ ID NOS:
515, 516 and 517;
heavy chain CDR1-3 of SEQ ID NOS:
326, 327 and 328, and light chain CDR1-3 of SEQ ID NOS:
518, 519 and 520;
heavy chain CDR1-3 of SEQ ID NOS:
329, 330 and 331, and light chain CDR1-3 of SEQ ID NOS:
521, 522 and 523;
heavy chain CDR1-3 of SEQ ID NOS:
332, 333 and 334, and light chain CDR1-3 of SEQ ID NOS:
524, 525 and 526;
heavy chain CDR1-3 of SEQ ID NOS:
335, 336 and 337, and light chain CDR1-3 of SEQ ID NOS:
527, 528 and 529;
heavy chain CDR1-3 of SEQ ID NOS:
338, 339 and 340, and light chain CDR1-3 of SEQ ID NOS:
530, 531 and 532;
heavy chain CDR1-3 of SEQ ID NOS:
341, 342 and 343, and light chain CDR1-3 of SEQ ID NOS:
533, 534 and 535;
heavy chain CDR1-3 of SEQ ID NOS:
344, 345 and 346, and light chain CDR1-3 of SEQ ID NOS:
536, 537 and 538;
heavy chain CDR1-3 of SEQ ID NOS:
347, 348 and 349, and light chain CDR1-3 of SEQ ID NOS:
539, 540 and 541;
heavy chain CDR1-3 of SEQ ID NOS:
350, 351 and 352, and light chain CDR1-3 of SEQ ID NOS:
542, 543 and 544;
heavy chain CDR1-3 of SEQ ID NOS:
353, 354 and 355, and light chain CDR1-3 of SEQ ID NOS:
545, 546 and 547;
heavy chain CDR1-3 of SEQ ID NOS:
356, 357 and 358, and light chain CDR1-3 of SEQ ID NOS:
548, 549 and 550;
heavy chain CDR1-3 of SEQ ID NOS:
359, 360 and 361, and light chain CDR1-3 of SEQ ID NOS:
551, 552 and 553;
heavy chain CDR1-3 of SEQ ID NOS:
362, 363 and 364, and light chain CDR1-3 of SEQ ID NOS:
554, 555 and 556;
heavy chain CDR1-3 of SEQ ID NOS:
365, 366 and 367, and light chain CDR1-3 of SEQ ID NOS:
557, 558 and 559;
heavy chain CDR1-3 of SEQ ID NOS:
368, 369 and 370, and light chain CDR1-3 of SEQ ID NOS:
560, 561 and 562;
heavy chain CDR1-3 of SEQ ID NOS:
371, 372 and 373, and light chain CDR1-3 of SEQ ID NOS:
563, 564 and 565;
heavy chain CDR1-3 of SEQ ID NOS:
374, 375 and 376, and light chain CDR1-3 of SEQ ID NOS:
566, 567 and 568;
heavy chain CDR1-3 of SEQ ID NOS:
377, 378 and 379, and light chain CDR1-3 of SEQ ID NOS:
569, 570 and 571;
heavy chain CDR1-3 of SEQ ID NOS:
380, 381 and 382, and light chain CDR1-3 of SEQ ID NOS:
572, 573 and 574;
heavy chain CDR1-3 of SEQ ID NOS:
383, 384 and 385, and light chain CDR1-3 of SEQ ID NOS:
575, 576 and 577;
heavy chain CDR1-3 of SEQ ID NOS:
386, 387 and 388, and light chain CDR1-3 of SEQ ID NOS:
578, 579 and 580;
heavy chain CDR1-3 of SEQ ID NOS:
389, 390 and 391, and light chain CDR1-3 of SEQ ID NOS:
581, 582 and 583;
heavy chain CDR1-3 of SEQ ID NOS:
392, 393 and 394, and light chain CDR1-3 of SEQ ID NOS:
584, 585 and 586;
heavy chain CDR1-3 of SEQ ID NOS:
395, 396 and 397, and light chain CDR1-3 of SEQ ID NOS:
587, 588 and 589;
heavy chain CDR1-3 of SEQ ID NOS:
398, 399 and 400, and light chain CDR1-3 of SEQ ID NOS:
590, 591 and 592;
heavy chain CDR1-3 of SEQ ID NOS:
401, 402 and 403, and light chain CDR1-3 of SEQ ID NOS:
593, 594 and 595;
heavy chain CDR1-3 of SEQ ID NOS:
404, 405 and 406, and light chain CDR1-3 of SEQ ID NOS:
596, 597 and 598;
heavy chain CDR1-3 of SEQ ID NOS:
407, 408 and 409, and light chain CDR1-3 of SEQ ID NOS:
599, 600 and 601;
heavy chain CDR1-3 of SEQ ID NOS:
410, 411 and 412, and light chain CDR1-3 of SEQ ID NOS:
602, 603 and 604;
heavy chain CDR1-3 of SEQ ID NOS:
413, 414 and 415, and light chain CDR1-3 of SEQ ID NOS:
605, 606 and 607;
heavy chain CDR1-3 of SEQ ID NOS:
416, 417 and 418, and light chain CDR1-3 of SEQ ID NOS:
608, 609 and 610;
heavy chain CDR1-3 of SEQ ID NOS:
419, 420 and 421, and light chain CDR1-3 of SEQ ID NOS:
611, 612 and 613;
heavy chain CDR1-3 of SEQ ID NOS:
422, 423 and 424, and light chain CDR1-3 of SEQ ID NOS:
614, 615 and 616;
heavy chain CDR1-3 of SEQ ID NOS:
425, 426 and 427, and light chain CDR1-3 of SEQ ID NOS:
617, 618 and 619;
heavy chain CDR1-3 of SEQ ID NOS:
428, 429 and 430, and light chain CDR1-3 of SEQ ID NOS:
620, 621 and 622;
heavy chain CDR1-3 of SEQ ID NOS:
431, 432 and 433, and light chain CDR1-3 of SEQ ID NOS:
623, 624 and 625;
heavy chain CDR1-3 of SEQ ID NOS:
434, 435 and 436, and light chain CDR1-3 of SEQ ID NOS:
626, 627 and 628;
heavy chain CDR1-3 of SEQ ID NOS:
437, 438 and 439, and light chain CDR1-3 of SEQ ID NOS:
629, 630 and 631;
heavy chain CDR1-3 of SEQ ID NOS:
440, 441 and 442, and light chain CDR1-3 of SEQ ID NOS:
632, 633 and 634;
heavy chain CDR1-3 of SEQ ID NOS:
443, 444 and 445, and light chain CDR1-3 of SEQ ID NOS:
635, 636 and 637;
or heavy chain CDR1-3 of SEQ ID NOS:
446, 447 and 448, and light chain CDR1-3 of SEQ ID NOS:
638, 639 and 640.

188 more elements

A method of detecting enterovirus D68 (EV-D68) infection in a subject comprising:

(a) contacting a sample from said subject with an antibody or antibody fragment comprising heavy chain CDR1-3 of SEQ ID NOS:
257, 258 and 259, and light chain CDR1-3 of SEQ ID NOS:
449, 450 and 451;
heavy chain CDR1-3 of SEQ ID NOS:
260, 261 and 262, and light chain CDR1-3 of SEQ ID NOS:
452, 453 and 454;
heavy chain CDR1-3 of SEQ ID NOS:
263, 264 and 265, and light chain CDR1-3 of SEQ ID NOS:
455, 456 and 457;
heavy chain CDR1-3 of SEQ ID NOS:
266, 267 and 268, and light chain CDR1-3 of SEQ ID NOS:
458, 459 and 460;
heavy chain CDR1-3 of SEQ ID NOS:
269, 270 and 271, and light chain CDR1-3 of SEQ ID NOS:
461, 462 and 463;
heavy chain CDR1-3 of SEQ ID NOS:
272, 273 and 274, and light chain CDR1-3 of SEQ ID NOS:
464, 465 and 466;
heavy chain CDR1-3 of SEQ ID NOS:
275, 276 and 277, and light chain CDR1-3 of SEQ ID NOS:
467, 468 and 469;
heavy chain CDR1-3 of SEQ ID NOS:
278, 279 and 280, and light chain CDR1-3 of SEQ ID NOS:
470, 471 and 472;
heavy chain CDR1-3 of SEQ ID NOS:
281, 282 and 283, and light chain CDR1-3 of SEQ ID NOS:
473, 474 and 475;
heavy chain CDR1-3 of SEQ ID NOS:
284, 285 and 286, and light chain CDR1-3 of SEQ ID NOS:
476, 477 and 478;
heavy chain CDR1-3 of SEQ ID NOS:
287, 288 and 289, and light chain CDR1-3 of SEQ ID NOS:
479, 480 and 481;
heavy chain CDR1-3 of SEQ ID NOS:
290, 291 and 292, and light chain CDR1-3 of SEQ ID NOS:
482, 483 and 484;
heavy chain CDR1-3 of SEQ ID NOS:
293, 294 and 295, and light chain CDR1-3 of SEQ ID NOS:
485, 486 and 487;
heavy chain CDR1-3 of SEQ ID NOS:
296, 297 and 298, and light chain CDR1-3 of SEQ ID NOS:
488, 489 and 490;
heavy chain CDR1-3 of SEQ ID NOS:
299, 300 and 301, and light chain CDR1-3 of SEQ ID NOS:
491, 492 and 493;
heavy chain CDR1-3 of SEQ ID NOS:
302, 303 and 304, and light chain CDR1-3 of SEQ ID NOS:
494, 495 and 496;
heavy chain CDR1-3 of SEQ ID NOS:
305, 306 and 307, and light chain CDR1-3 of SEQ ID NOS:
497, 498 and 499;
heavy chain CDR1-3 of SEQ ID NOS:
308, 309 and 310, and light chain CDR1-3 of SEQ ID NOS:
500, 501 and 502;
heavy chain CDR1-3 of SEQ ID NOS:
311, 312 and 313, and light chain CDR1-3 of SEQ ID NOS:
503, 504 and 505;
heavy chain CDR1-3 of SEQ ID NOS:
314, 315 and 316, and light chain CDR1-3 of SEQ ID NOS:
506, 507 and 508;
heavy chain CDR1-3 of SEQ ID NOS:
317, 318 and 319, and light chain CDR1-3 of SEQ ID NOS:
509, 510 and 511;
heavy chain CDR1-3 of SEQ ID NOS:
320, 321 and 322, and light chain CDR1-3 of SEQ ID NOS:
512, 513 and 514;
heavy chain CDR1-3 of SEQ ID NOS:
323, 324 and 325, and light chain CDR1-3 of SEQ ID NOS:
515, 516 and 517;
heavy chain CDR1-3 of SEQ ID NOS:
326, 327 and 328, and light chain CDR1-3 of SEQ ID NOS:
518, 519 and 520;
heavy chain CDR1-3 of SEQ ID NOS:
329, 330 and 331, and light chain CDR1-3 of SEQ ID NOS:
521, 522 and 523;
heavy chain CDR1-3 of SEQ ID NOS:
332, 333 and 334, and light chain CDR1-3 of SEQ ID NOS:
524, 525 and 526;
heavy chain CDR1-3 of SEQ ID NOS:
335, 336 and 347, and light chain CDR1-3 of SEQ ID NOS:
527, 528 and 529;
heavy chain CDR1-3 of SEQ ID NOS:
338, 339 and 340, and light chain CDR1-3 of SEQ ID NOS:
530, 531 and 532;
heavy chain CDR1-3 of SEQ ID NOS:
341, 342 and 343, and light chain CDR1-3 of SEQ ID NOS:
533, 534 and 535;
heavy chain CDR1-3 of SEQ ID NOS:
344, 345 and 346, and light chain CDR1-3 of SEQ ID NOS:
536, 537 and 538;
heavy chain CDR1-3 of SEQ ID NOS:
337, 348 and 349, and light chain CDR1-3 of SEQ ID NOS:
539, 540 and 541;
heavy chain CDR1-3 of SEQ ID NOS:
350, 351 and 352, and light chain CDR1-3 of SEQ ID NOS:
542, 543 and 544;
heavy chain CDR1-3 of SEQ ID NOS:
353, 354 and 355, and light chain CDR1-3 of SEQ ID NOS:
545, 546 and 547;
heavy chain CDR1-3 of SEQ ID NOS:
356, 357 and 358, and light chain CDR1-3 of SEQ ID NOS:
548, 549 and 550;
heavy chain CDR1-3 of SEQ ID NOS:
359, 360 and 361, and light chain CDR1-3 of SEQ ID NOS:
551, 552 and 553;
heavy chain CDR1-3 of SEQ ID NOS:
362, 363 and 364, and light chain CDR1-3 of SEQ ID NOS:
554, 555 and 556;
heavy chain CDR1-3 of SEQ ID NOS:
365, 366 and 367, and light chain CDR1-3 of SEQ ID NOS:
557, 558 and 559;
heavy chain CDR1-3 of SEQ ID NOS:
368, 369 and 370, and light chain CDR1-3 of SEQ ID NOS:
560, 561 and 562;
heavy chain CDR1-3 of SEQ ID NOS:
371, 372 and 373, and light chain CDR1-3 of SEQ ID NOS:
563, 564 and 565;
heavy chain CDR1-3 of SEQ ID NOS:
374, 375 and 376, and light chain CDR1-3 of SEQ ID NOS:
566, 567 and 568;
heavy chain CDR1-3 of SEQ ID NOS:
377, 378 and 379, and light chain CDR1-3 of SEQ ID NOS:
569, 570 and 571;
heavy chain CDR1-3 of SEQ ID NOS:
380, 381 and 382, and light chain CDR1-3 of SEQ ID NOS:
572, 573 and 574;
heavy chain CDR1-3 of SEQ ID NOS:
383, 384 and 385, and light chain CDR1-3 of SEQ ID NOS:
575, 576 and 577;
heavy chain CDR1-3 of SEQ ID NOS:
386, 387 and 388, and light chain CDR1-3 of SEQ ID NOS:
578, 579 and 580;
heavy chain CDR1-3 of SEQ ID NOS:
389, 390 and 391, and light chain CDR1-3 of SEQ ID NOS:
581, 582 and 583;
heavy chain CDR1-3 of SEQ ID NOS:
392, 393 and 394, and light chain CDR1-3 of SEQ ID NOS:
584, 585 and 586;
heavy chain CDR1-3 of SEQ ID NOS:
395, 396 and 397, and light chain CDR1-3 of SEQ ID NOS:
587, 588 and 589;
heavy chain CDR1-3 of SEQ ID NOS:
398, 399 and 400, and light chain CDR1-3 of SEQ ID NOS:
590, 591 and 592;
heavy chain CDR1-3 of SEQ ID NOS:
401, 402 and 403, and light chain CDR1-3 of SEQ ID NOS:
593, 594 and 595;
heavy chain CDR1-3 of SEQ ID NOS:
404, 405 and 406, and light chain CDR1-3 of SEQ ID NOS:
596, 597 and 598;
heavy chain CDR1-3 of SEQ ID NOS:
407, 408 and 409, and light chain CDR1-3 of SEQ ID NOS:
599, 600 and 601;
heavy chain CDR1-3 of SEQ ID NOS:
410, 411 and 412, and light chain CDR1-3 of SEQ ID NOS:
602, 603 and 604;
heavy chain CDR1-3 of SEQ ID NOS:
413, 414 and 415, and light chain CDR1-3 of SEQ ID NOS:
605, 606 and 607;
heavy chain CDR1-3 of SEQ ID NOS:
416, 417 and 418, and light chain CDR1-3 of SEQ ID NOS:
608, 609 and 610;
heavy chain CDR1-3 of SEQ ID NOS:
419, 420 and 421, and light chain CDR1-3 of SEQ ID NOS:
611, 612 and 613;
heavy chain CDR1-3 of SEQ ID NOS:
422, 423 and 424, and light chain CDR1-3 of SEQ ID NOS:
614, 615 and 616;
heavy chain CDR1-3 of SEQ ID NOS:
425, 426 and 427, and light chain CDR1-3 of SEQ ID NOS:
617, 618 and 619;
heavy chain CDR1-3 of SEQ ID NOS:
428, 429 and 430, and light chain CDR1-3 of SEQ ID NOS:
620, 621 and 622;
heavy chain CDR1-3 of SEQ ID NOS:
431, 432 and 433, and light chain CDR1-3 of SEQ ID NOS:
623, 624 and 625;
heavy chain CDR1-3 of SEQ ID NOS:
434, 435 and 436, and light chain CDR1-3 of SEQ ID NOS:
626, 627 and 628;
heavy chain CDR1-3 of SEQ ID NOS:
437, 438 and 439, and light chain CDR1-3 of SEQ ID NOS:
629, 630 and 631;
heavy chain CDR1-3 of SEQ ID NOS:
440, 441 and 442, and light chain CDR1-3 of SEQ ID NOS:
632, 633 and 634;
heavy chain CDR1-3 of SEQ ID NOS:
443, 444 and 445, and light chain CDR1-3 of SEQ ID NOS:
635, 636 and 637;
or heavy chain CDR1-3 of SEQ ID NOS:
446, 447 and 448, and light chain CDR1-3 of SEQ ID NOS:
638, 639 and 640;
and
(b) detecting EV-D68 in said sample by binding of said antibody or antibody fragment to a EV-D68 antigen in said sample.

191 more elements

A monoclonal antibody or fragment thereof, wherein the antibody or antibody fragment comprises heavy chain CDR1-3 of SEQ ID NOS:

257, 258 and 259, and light chain CDR1-3 of SEQ ID NOS:
449, 450 and 451;
heavy chain CDR1-3 of SEQ ID NOS:
260, 261 and 262, and light chain CDR1-3 of SEQ ID NOS:
452, 453 and 454;
heavy chain CDR1-3 of SEQ ID NOS:
263, 264 and 265, and light chain CDR1-3 of SEQ ID NOS:
455, 456 and 457;
heavy chain CDR1-3 of SEQ ID NOS:
266, 267 and 268, and light chain CDR1-3 of SEQ ID NOS:
458, 459 and 460;
heavy chain CDR1-3 of SEQ ID NOS:
269, 270 and 271, and light chain CDR1-3 of SEQ ID NOS:
461, 462 and 463;
heavy chain CDR1-3 of SEQ ID NOS:
272, 273 and 274, and light chain CDR1-3 of SEQ ID NOS:
464, 465 and 466;
heavy chain CDR1-3 of SEQ ID NOS:
275, 276 and 277, and light chain CDR1-3 of SEQ ID NOS:
467, 468 and 469;
heavy chain CDR1-3 of SEQ ID NOS:
278, 279 and 280, and light chain CDR1-3 of SEQ ID NOS:
470, 471 and 472;
heavy chain CDR1-3 of SEQ ID NOS:
281, 282 and 283, and light chain CDR1-3 of SEQ ID NOS:
473, 474 and 475;
heavy chain CDR1-3 of SEQ ID NOS:
284, 285 and 286, and light chain CDR1-3 of SEQ ID NOS:
476, 477 and 478;
heavy chain CDR1-3 of SEQ ID NOS:
287, 288 and 289, and light chain CDR1-3 of SEQ ID NOS:
479, 480 and 481;
heavy chain CDR1-3 of SEQ ID NOS:
290, 291 and 292, and light chain CDR1-3 of SEQ ID NOS:
482, 483 and 484;
heavy chain CDR1-3 of SEQ ID NOS:
293, 294 and 295, and light chain CDR1-3 of SEQ ID NOS:
485, 486 and 487;
heavy chain CDR1-3 of SEQ ID NOS:
296, 297 and 298, and light chain CDR1-3 of SEQ ID NOS:
488, 489 and 490;
heavy chain CDR1-3 of SEQ ID NOS:
299, 300 and 301, and light chain CDR1-3 of SEQ ID NOS:
491, 492 and 493;
heavy chain CDR1-3 of SEQ ID NOS:
302, 303 and 304, and light chain CDR1-3 of SEQ ID NOS:
494, 495 and 496;
heavy chain CDR1-3 of SEQ ID NOS:
305, 306 and 307, and light chain CDR1-3 of SEQ ID NOS:
497, 498 and 499;
heavy chain CDR1-3 of SEQ ID NOS:
308, 309 and 310, and light chain CDR1-3 of SEQ ID NOS:
500, 501 and 502;
heavy chain CDR1-3 of SEQ ID NOS:
311, 312 and 313, and light chain CDR1-3 of SEQ ID NOS:
503, 504 and 505;
heavy chain CDR1-3 of SEQ ID NOS:
314, 315 and 316, and light chain CDR1-3 of SEQ ID NOS:
506, 507 and 508;
heavy chain CDR1-3 of SEQ ID NOS:
317, 318 and 319, and light chain CDR1-3 of SEQ ID NOS:
509, 510 and 511;
heavy chain CDR1-3 of SEQ ID NOS:
320, 321 and 322, and light chain CDR1-3 of SEQ ID NOS:
512, 513 and 514;
heavy chain CDR1-3 of SEQ ID NOS:
323, 324 and 325, and light chain CDR1-3 of SEQ ID NOS:
515, 516 and 517;
heavy chain CDR1-3 of SEQ ID NOS:
326, 327 and 328, and light chain CDR1-3 of SEQ ID NOS:
518, 519 and 520;
heavy chain CDR1-3 of SEQ ID NOS:
329, 330 and 331, and light chain CDR1-3 of SEQ ID NOS:
521, 522 and 523;
heavy chain CDR1-3 of SEQ ID NOS:
332, 333 and 334, and light chain CDR1-3 of SEQ ID NOS:
524, 525 and 526;
heavy chain CDR1-3 of SEQ ID NOS:
335, 336 and 337, and light chain CDR1-3 of SEQ ID NOS:
527, 528 and 529;
heavy chain CDR1-3 of SEQ ID NOS:
338, 339 and 340, and light chain CDR1-3 of SEQ ID NOS:
530, 531 and 532;
heavy chain CDR1-3 of SEQ ID NOS:
341, 342 and 343, and light chain CDR1-3 of SEQ ID NOS:
533, 534 and 535;
heavy chain CDR1-3 of SEQ ID NOS:
344, 345 and 346, and light chain CDR1-3 of SEQ ID NOS:
536, 537 and 538;
heavy chain CDR1-3 of SEQ ID NOS:
347, 348 and 349, and light chain CDR1-3 of SEQ ID NOS:
539, 540 and 541;
heavy chain CDR1-3 of SEQ ID NOS:
350, 351 and 352, and light chain CDR1-3 of SEQ ID NOS:
542, 543 and 544;
heavy chain CDR1-3 of SEQ ID NOS:
353, 354 and 355, and light chain CDR1-3 of SEQ ID NOS:
545, 546 and 547;
heavy chain CDR1-3 of SEQ ID NOS:
356, 357 and 358, and light chain CDR1-3 of SEQ ID NOS:
548, 549 and 550;
heavy chain CDR1-3 of SEQ ID NOS:
359, 360 and 361, and light chain CDR1-3 of SEQ ID NOS:
551, 552 and 553;
heavy chain CDR1-3 of SEQ ID NOS:
362, 363 and 364, and light chain CDR1-3 of SEQ ID NOS:
554, 555 and 556;
heavy chain CDR1-3 of SEQ ID NOS:
365, 366 and 367, and light chain CDR1-3 of SEQ ID NOS:
557, 558 and 559;
heavy chain CDR1-3 of SEQ ID NOS:
368, 369 and 370, and light chain CDR1-3 of SEQ ID NOS:
560, 561 and 562;
heavy chain CDR1-3 of SEQ ID NOS:
371, 372 and 373, and light chain CDR1-3 of SEQ ID NOS:
563, 564 and 565;
heavy chain CDR1-3 of SEQ ID NOS:
374, 375 and 376, and light chain CDR1-3 of SEQ ID NOS:
566, 567 and 568;
heavy chain CDR1-3 of SEQ ID NOS:
377, 378 and 379, and light chain CDR1-3 of SEQ ID NOS:
569, 570 and 571;
heavy chain CDR1-3 of SEQ ID NOS:
380, 381 and 382, and light chain CDR1-3 of SEQ ID NOS:
572, 573 and 574;
heavy chain CDR1-3 of SEQ ID NOS:
383, 384 and 385, and light chain CDR1-3 of SEQ ID NOS:
575, 576 and 577;
heavy chain CDR1-3 of SEQ ID NOS:
386, 387 and 388, and light chain CDR1-3 of SEQ ID NOS:
578, 579 and 580;
heavy chain CDR1-3 of SEQ ID NOS:
389, 390 and 391, and light chain CDR1-3 of SEQ ID NOS:
581, 582 and 583;
heavy chain CDR1-3 of SEQ ID NOS:
392, 393 and 394, and light chain CDR1-3 of SEQ ID NOS:
584, 585 and 586;
heavy chain CDR1-3 of SEQ ID NOS:
395, 396 and 397, and light chain CDR1-3 of SEQ ID NOS:
587, 588 and 589;
heavy chain CDR1-3 of SEQ ID NOS:
398, 399 and 400, and light chain CDR1-3 of SEQ ID NOS:
590, 591 and 592;
heavy chain CDR1-3 of SEQ ID NOS:
401, 402 and 403, and light chain CDR1-3 of SEQ ID NOS:
593, 594 and 595;
heavy chain CDR1-3 of SEQ ID NOS:
404, 405 and 406, and light chain CDR1-3 of SEQ ID NOS:
596, 597 and 598;
heavy chain CDR1-3 of SEQ ID NOS:
407, 408 and 409, and light chain CDR1-3 of SEQ ID NOS:
599, 600 and 601;
heavy chain CDR1-3 of SEQ ID NOS:
410, 411 and 412, and light chain CDR1-3 of SEQ ID NOS:
602, 603 and 604;
heavy chain CDR1-3 of SEQ ID NOS:
413, 414 and 415, and light chain CDR1-3 of SEQ ID NOS:
605, 606 and 607;
heavy chain CDR1-3 of SEQ ID NOS:
416, 417 and 418, and light chain CDR1-3 of SEQ ID NOS:
608, 609 and 610;
heavy chain CDR1-3 of SEQ ID NOS:
419, 420 and 421, and light chain CDR1-3 of SEQ ID NOS:
611, 612 and 613;
heavy chain CDR1-3 of SEQ ID NOS:
422, 423 and 424, and light chain CDR1-3 of SEQ ID NOS:
614, 615 and 616;
heavy chain CDR1-3 of SEQ ID NOS:
425, 426 and 427, and light chain CDR1-3 of SEQ ID NOS:
617, 618 and 619;
heavy chain CDR1-3 of SEQ ID NOS:
428, 429 and 430, and light chain CDR1-3 of SEQ ID NOS:
620, 621 and 622;
heavy chain CDR1-3 of SEQ ID NOS:
431, 432 and 433, and light chain CDR1-3 of SEQ ID NOS:
623, 624 and 625;
heavy chain CDR1-3 of SEQ ID NOS:
434, 435 and 436, and light chain CDR1-3 of SEQ ID NOS:
626, 627 and 628;
heavy chain CDR1-3 of SEQ ID NOS:
437, 438 and 439, and light chain CDR1-3 of SEQ ID NOS:
629, 630 and 631;
heavy chain CDR1-3 of SEQ ID NOS:
440, 441 and 442, and light chain CDR1-3 of SEQ ID NOS:
632, 633 and 634;
heavy chain CDR1-3 of SEQ ID NOS:
443, 444 and 445, and light chain CDR1-3 of SEQ ID NOS:
635, 636 and 637;
or heavy chain CDR1-3 of SEQ ID NOS:
446, 447 and 448, and light chain CDR1-3 of SEQ ID NOS:
638, 639 and 640, wherein said antibody is a chimeric antibody or a bispecific antibody, and said antibody fragment is an scFv (single chain fragment variable).

188 more elements

A hybridoma or engineered cell encoding an antibody or antibody fragment, wherein the antibody or antibody fragment comprises heavy chain CDR1-3 of SEQ ID NOS:

257, 258 and 259, and light chain CDR1-3 of SEQ ID NOS:
449, 450 and 451;
heavy chain CDR1-3 of SEQ ID NOS:
260, 261 and 262, and light chain CDR1-3 of SEQ ID NOS:
452, 453 and 454;
heavy chain CDR1-3 of SEQ ID NOS:
263, 264 and 265, and light chain CDR1-3 of SEQ ID NOS:
455, 456 and 457;
heavy chain CDR1-3 of SEQ ID NOS:
266, 267 and 268, and light chain CDR1-3 of SEQ ID NOS:
458, 459 and 460;
heavy chain CDR1-3 of SEQ ID NOS:
269, 270 and 271, and light chain CDR1-3 of SEQ ID NOS:
461, 462 and 463;
heavy chain CDR1-3 of SEQ ID NOS:
272, 273 and 274, and light chain CDR1-3 of SEQ ID NOS:
464, 465 and 466;
heavy chain CDR1-3 of SEQ ID NOS:
275, 276 and 277, and light chain CDR1-3 of SEQ ID NOS:
467, 468 and 469;
heavy chain CDR1-3 of SEQ ID NOS:
278, 279 and 280, and light chain CDR1-3 of SEQ ID NOS:
470, 471 and 472;
heavy chain CDR1-3 of SEQ ID NOS:
281, 282 and 283, and light chain CDR1-3 of SEQ ID NOS:
473, 474 and 475;
heavy chain CDR1-3 of SEQ ID NOS:
284, 285 and 286, and light chain CDR1-3 of SEQ ID NOS:
476, 477 and 478;
heavy chain CDR1-3 of SEQ ID NOS:
287, 288 and 289, and light chain CDR1-3 of SEQ ID NOS:
479, 480 and 481;
heavy chain CDR1-3 of SEQ ID NOS:
290, 291 and 292, and light chain CDR1-3 of SEQ ID NOS:
482, 483 and 484;
heavy chain CDR1-3 of SEQ ID NOS:
293, 294 and 295, and light chain CDR1-3 of SEQ ID NOS:
485, 486 and 487;
heavy chain CDR1-3 of SEQ ID NOS:
296, 297 and 298, and light chain CDR1-3 of SEQ ID NOS:
488, 489 and 490;
heavy chain CDR1-3 of SEQ ID NOS:
299, 300 and 301, and light chain CDR1-3 of SEQ ID NOS:
491, 492 and 493;
heavy chain CDR1-3 of SEQ ID NOS:
302, 303 and 304, and light chain CDR1-3 of SEQ ID NOS:
494, 495 and 496;
heavy chain CDR1-3 of SEQ ID NOS:
305, 306 and 307, and light chain CDR1-3 of SEQ ID NOS:
497, 498 and 499;
heavy chain CDR1-3 of SEQ ID NOS:
308, 309 and 310, and light chain CDR1-3 of SEQ ID NOS:
500, 501 and 502;
heavy chain CDR1-3 of SEQ ID NOS:
311, 312 and 313, and light chain CDR1-3 of SEQ ID NOS:
503, 504 and 505;
heavy chain CDR1-3 of SEQ ID NOS:
314, 315 and 316, and light chain CDR1-3 of SEQ ID NOS:
506, 507 and 508;
heavy chain CDR1-3 of SEQ ID NOS:
317, 318 and 319, and light chain CDR1-3 of SEQ ID NOS:
509, 510 and 511;
heavy chain CDR1-3 of SEQ ID NOS:
320, 321 and 322, and light chain CDR1-3 of SEQ ID NOS:
512, 513 and 514;
heavy chain CDR1-3 of SEQ ID NOS:
323, 324 and 325, and light chain CDR1-3 of SEQ ID NOS:
515, 516 and 517;
heavy chain CDR1-3 of SEQ ID NOS:
326, 327 and 328, and light chain CDR1-3 of SEQ ID NOS:
518, 519 and 520;
heavy chain CDR1-3 of SEQ ID NOS:
329, 330 and 331, and light chain CDR1-3 of SEQ ID NOS:
521, 522 and 523;
heavy chain CDR1-3 of SEQ ID NOS:
332, 333 and 334, and light chain CDR1-3 of SEQ ID NOS:
524, 525 and 526;
heavy chain CDR1-3 of SEQ ID NOS:
335, 336 and 337, and light chain CDR1-3 of SEQ ID NOS:
527, 528 and 529;
heavy chain CDR1-3 of SEQ ID NOS:
338, 339 and 340, and light chain CDR1-3 of SEQ ID NOS:
530, 531 and 532;
heavy chain CDR1-3 of SEQ ID NOS:
341, 342 and 343, and light chain CDR1-3 of SEQ ID NOS:
533, 534 and 535;
heavy chain CDR1-3 of SEQ ID NOS:
344, 345 and 346, and light chain CDR1-3 of SEQ ID NOS:
536, 537 and 538;
heavy chain CDR1-3 of SEQ ID NOS:
347, 348 and 349, and light chain CDR1-3 of SEQ ID NOS:
539, 540 and 541;
heavy chain CDR1-3 of SEQ ID NOS:
350, 351 and 352, and light chain CDR1-3 of SEQ ID NOS:
542, 543 and 544;
heavy chain CDR1-3 of SEQ ID NOS:
353, 354 and 355, and light chain CDR1-3 of SEQ ID NOS:
545, 546 and 547;
heavy chain CDR1-3 of SEQ ID NOS:
356, 357 and 358, and light chain CDR1-3 of SEQ ID NOS:
548, 549 and 550;
heavy chain CDR1-3 of SEQ ID NOS:
359, 360 and 361, and light chain CDR1-3 of SEQ ID NOS:
551, 552 and 553;
heavy chain CDR1-3 of SEQ ID NOS:
362, 363 and 364, and light chain CDR1-3 of SEQ ID NOS:
554, 555 and 556;
heavy chain CDR1-3 of SEQ ID NOS:
365, 366 and 367, and light chain CDR1-3 of SEQ ID NOS:
557, 558 and 559;
heavy chain CDR1-3 of SEQ ID NOS:
368, 369 and 370, and light chain CDR1-3 of SEQ ID NOS:
560, 561 and 562;
heavy chain CDR1-3 of SEQ ID NOS:
371, 372 and 373, and light chain CDR1-3 of SEQ ID NOS:
563, 564 and 565;
heavy chain CDR1-3 of SEQ ID NOS:
374, 375 and 376, and light chain CDR1-3 of SEQ ID NOS:
566, 567 and 568;
heavy chain CDR1-3 of SEQ ID NOS:
377, 378 and 379, and light chain CDR1-3 of SEQ ID NOS:
569, 570 and 571;
heavy chain CDR1-3 of SEQ ID NOS:
380, 381 and 382, and light chain CDR1-3 of SEQ ID NOS:
572, 573 and 574;
heavy chain CDR1-3 of SEQ ID NOS:
383, 384 and 385, and light chain CDR1-3 of SEQ ID NOS:
575, 576 and 577;
heavy chain CDR1-3 of SEQ ID NOS:
386, 387 and 388, and light chain CDR1-3 of SEQ ID NOS:
578, 579 and 580;
heavy chain CDR1-3 of SEQ ID NOS:
389, 390 and 391, and light chain CDR1-3 of SEQ ID NOS:
581, 582 and 583;
heavy chain CDR1-3 of SEQ ID NOS:
392, 393 and 394, and light chain CDR1-3 of SEQ ID NOS:
584, 585 and 586;
heavy chain CDR1-3 of SEQ ID NOS:
395, 396 and 397, and light chain CDR1-3 of SEQ ID NOS:
587, 588 and 589;
heavy chain CDR1-3 of SEQ ID NOS:
398, 399 and 400, and light chain CDR1-3 of SEQ ID NOS:
590, 591 and 592;
heavy chain CDR1-3 of SEQ ID NOS:
401, 402 and 403, and light chain CDR1-3 of SEQ ID NOS:
593, 594 and 595;
heavy chain CDR1-3 of SEQ ID NOS:
404, 405 and 406, and light chain CDR1-3 of SEQ ID NOS:
596, 597 and 598;
heavy chain CDR1-3 of SEQ ID NOS:
407, 408 and 409, and light chain CDR1-3 of SEQ ID NOS:
599, 600 and 601;
heavy chain CDR1-3 of SEQ ID NOS:
410, 411 and 412, and light chain CDR1-3 of SEQ ID NOS:
602, 603 and 604;
heavy chain CDR1-3 of SEQ ID NOS:
413, 414 and 415, and light chain CDR1-3 of SEQ ID NOS:
605, 606 and 607;
heavy chain CDR1-3 of SEQ ID NOS:
416, 417 and 418, and light chain CDR1-3 of SEQ ID NOS:
608, 609 and 610;
heavy chain CDR1-3 of SEQ ID NOS:
419, 420 and 421, and light chain CDR1-3 of SEQ ID NOS:
611, 612 and 613;
heavy chain CDR1-3 of SEQ ID NOS:
422, 423 and 424, and light chain CDR1-3 of SEQ ID NOS:
614, 615 and 616;
heavy chain CDR1-3 of SEQ ID NOS:
425, 426 and 427, and light chain CDR1-3 of SEQ ID NOS:
617, 618 and 619;
heavy chain CDR1-3 of SEQ ID NOS:
428, 429 and 430, and light chain CDR1-3 of SEQ ID NOS:
620, 621 and 622;
heavy chain CDR1-3 of SEQ ID NOS:
431, 432 and 433, and light chain CDR1-3 of SEQ ID NOS:
623, 624 and 625;
heavy chain CDR1-3 of SEQ ID NOS:
434, 435 and 436, and light chain CDR1-3 of SEQ ID NOS:
626, 627 and 628;
heavy chain CDR1-3 of SEQ ID NOS:
437, 438 and 439, and light chain CDR1-3 of SEQ ID NOS:
629, 630 and 631;
heavy chain CDR1-3 of SEQ ID NOS:
440, 441 and 442, and light chain CDR1-3 of SEQ ID NOS:
632, 633 and 634;
heavy chain CDR1-3 of SEQ ID NOS:
443, 444 and 445, and light chain CDR1-3 of SEQ ID NOS:
635, 636 and 637;
or heavy chain CDR1-3 of SEQ ID NOS:
446, 447 and 448, and light chain CDR1-3 of SEQ ID NOS:
638, 639 and 640.

188 more elements

Dependencies are inferred from the claim text.

Facts

Application: 17/630,053Filed 24 Jul 2020 · us provisional application
Priority: 26 Jul 2019
Published: US 2022/0289828 A115 Sep 2022
Granted: 9 Sep 2025
Term ends: Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07K 16/106
RNA viruses: picornaviridae , e.g. hepatitis A virus
A61K 39/42
Antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum: viral
A61P 31/14
Antivirals: for RNA viruses
C07K 16/10
Against material from viruses: rNA viruses

Family

Application62/878,955Us provisional application · filed 26 Jul 2019
Application62/899,503Us provisional application · filed 12 Sep 2019
Application63/047,330Us provisional application · filed 2 Jul 2020
US 2022/0289828 A1Pre-grant publication · published 15 Sep 2022
US 12,410,241 B2This patent

From the US filing history. Foreign family members aren’t listed.

Timeline

Citations

Open elsewhere

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Abstract

257, 258 and 259, and light chain CDR1-3 of SEQ ID NOS:
449, 450 and 451;
heavy chain CDR1-3 of SEQ ID NOS:
260, 261 and 262, and light chain CDR1-3 of SEQ ID NOS:
452, 453 and 454;
heavy chain CDR1-3 of SEQ ID NOS:
263, 264 and 265, and light chain CDR1-3 of SEQ ID NOS:
455, 456 and 457;
heavy chain CDR1-3 of SEQ ID NOS:
266, 267 and 268, and light chain CDR1-3 of SEQ ID NOS:
458, 459 and 460;
heavy chain CDR1-3 of SEQ ID NOS:
269, 270 and 271, and light chain CDR1-3 of SEQ ID NOS:
461, 462 and 463;
heavy chain CDR1-3 of SEQ ID NOS:
272, 273 and 274, and light chain CDR1-3 of SEQ ID NOS:
464, 465 and 466;
heavy chain CDR1-3 of SEQ ID NOS:
275, 276 and 277, and light chain CDR1-3 of SEQ ID NOS:
467, 468 and 469;
heavy chain CDR1-3 of SEQ ID NOS:
278, 279 and 280, and light chain CDR1-3 of SEQ ID NOS:
470, 471 and 472;
heavy chain CDR1-3 of SEQ ID NOS:
281, 282 and 283, and light chain CDR1-3 of SEQ ID NOS:
473, 474 and 475;
heavy chain CDR1-3 of SEQ ID NOS:
284, 285 and 286, and light chain CDR1-3 of SEQ ID NOS:
476, 477 and 478;
heavy chain CDR1-3 of SEQ ID NOS:
287, 288 and 289, and light chain CDR1-3 of SEQ ID NOS:
479, 480 and 481;
heavy chain CDR1-3 of SEQ ID NOS:
290, 291 and 292, and light chain CDR1-3 of SEQ ID NOS:
482, 483 and 484;
heavy chain CDR1-3 of SEQ ID NOS:
293, 294 and 295, and light chain CDR1-3 of SEQ ID NOS:
485, 486 and 487;
heavy chain CDR1-3 of SEQ ID NOS:
296, 297 and 298, and light chain CDR1-3 of SEQ ID NOS:
488, 489 and 490;
heavy chain CDR1-3 of SEQ ID NOS:
299, 300 and 301, and light chain CDR1-3 of SEQ ID NOS:
491, 492 and 493;
heavy chain CDR1-3 of SEQ ID NOS:
302, 303 and 304, and light chain CDR1-3 of SEQ ID NOS:
494, 495 and 496;
heavy chain CDR1-3 of SEQ ID NOS:
305, 306 and 307, and light chain CDR1-3 of SEQ ID NOS:
497, 498 and 499;
heavy chain CDR1-3 of SEQ ID NOS:
308, 309 and 310, and light chain CDR1-3 of SEQ ID NOS:
500, 501 and 502;
heavy chain CDR1-3 of SEQ ID NOS:
311, 312 and 313, and light chain CDR1-3 of SEQ ID NOS:
503, 504 and 505;
heavy chain CDR1-3 of SEQ ID NOS:
314, 315 and 316, and light chain CDR1-3 of SEQ ID NOS:
506, 507 and 508;
heavy chain CDR1-3 of SEQ ID NOS:
317, 318 and 319, and light chain CDR1-3 of SEQ ID NOS:
509, 510 and 511;
heavy chain CDR1-3 of SEQ ID NOS:
320, 321 and 322, and light chain CDR1-3 of SEQ ID NOS:
512, 513 and 514;
heavy chain CDR1-3 of SEQ ID NOS:
323, 324 and 325, and light chain CDR1-3 of SEQ ID NOS:
515, 516 and 517;
heavy chain CDR1-3 of SEQ ID NOS:
326, 327 and 328, and light chain CDR1-3 of SEQ ID NOS:
518, 519 and 520;
heavy chain CDR1-3 of SEQ ID NOS:
329, 330 and 331, and light chain CDR1-3 of SEQ ID NOS:
521, 522 and 523;
heavy chain CDR1-3 of SEQ ID NOS:
332, 333 and 334, and light chain CDR1-3 of SEQ ID NOS:
524, 525 and 526;
heavy chain CDR1-3 of SEQ ID NOS:
335, 336 and 337, and light chain CDR1-3 of SEQ ID NOS:
527, 528 and 529;
heavy chain CDR1-3 of SEQ ID NOS:
338, 339 and 340, and light chain CDR1-3 of SEQ ID NOS:
530, 531 and 532;
heavy chain CDR1-3 of SEQ ID NOS:
341, 342 and 343, and light chain CDR1-3 of SEQ ID NOS:
533, 534 and 535;
heavy chain CDR1-3 of SEQ ID NOS:
344, 345 and 346, and light chain CDR1-3 of SEQ ID NOS:
536, 537 and 538;
heavy chain CDR1-3 of SEQ ID NOS:
347, 348 and 349, and light chain CDR1-3 of SEQ ID NOS:
539, 540 and 541;
heavy chain CDR1-3 of SEQ ID NOS:
350, 351 and 352, and light chain CDR1-3 of SEQ ID NOS:
542, 543 and 544;
heavy chain CDR1-3 of SEQ ID NOS:
353, 354 and 355, and light chain CDR1-3 of SEQ ID NOS:
545, 546 and 547;
heavy chain CDR1-3 of SEQ ID NOS:
356, 357 and 358, and light chain CDR1-3 of SEQ ID NOS:
548, 549 and 550;
heavy chain CDR1-3 of SEQ ID NOS:
359, 360 and 361, and light chain CDR1-3 of SEQ ID NOS:
551, 552 and 553;
heavy chain CDR1-3 of SEQ ID NOS:
362, 363 and 364, and light chain CDR1-3 of SEQ ID NOS:
554, 555 and 556;
heavy chain CDR1-3 of SEQ ID NOS:
365, 366 and 367, and light chain CDR1-3 of SEQ ID NOS:
557, 558 and 559;
heavy chain CDR1-3 of SEQ ID NOS:
368, 369 and 370, and light chain CDR1-3 of SEQ ID NOS:
560, 561 and 562;
heavy chain CDR1-3 of SEQ ID NOS:
371, 372 and 373, and light chain CDR1-3 of SEQ ID NOS:
563, 564 and 565;
heavy chain CDR1-3 of SEQ ID NOS:
374, 375 and 376, and light chain CDR1-3 of SEQ ID NOS:
566, 567 and 568;
heavy chain CDR1-3 of SEQ ID NOS:
377, 378 and 379, and light chain CDR1-3 of SEQ ID NOS:
569, 570 and 571;
heavy chain CDR1-3 of SEQ ID NOS:
380, 381 and 382, and light chain CDR1-3 of SEQ ID NOS:
572, 573 and 574;
heavy chain CDR1-3 of SEQ ID NOS:
383, 384 and 385, and light chain CDR1-3 of SEQ ID NOS:
575, 576 and 577;
heavy chain CDR1-3 of SEQ ID NOS:
386, 387 and 388, and light chain CDR1-3 of SEQ ID NOS:
578, 579 and 580;
heavy chain CDR1-3 of SEQ ID NOS:
389, 390 and 391, and light chain CDR1-3 of SEQ ID NOS:
581, 582 and 583;
heavy chain CDR1-3 of SEQ ID NOS:
392, 393 and 394, and light chain CDR1-3 of SEQ ID NOS:
584, 585 and 586;
heavy chain CDR1-3 of SEQ ID NOS:
395, 396 and 397, and light chain CDR1-3 of SEQ ID NOS:
587, 588 and 589;
heavy chain CDR1-3 of SEQ ID NOS:
398, 399 and 400, and light chain CDR1-3 of SEQ ID NOS:
590, 591 and 592;
heavy chain CDR1-3 of SEQ ID NOS:
401, 402 and 403, and light chain CDR1-3 of SEQ ID NOS:
593, 594 and 595;
heavy chain CDR1-3 of SEQ ID NOS:
404, 405 and 406, and light chain CDR1-3 of SEQ ID NOS:
596, 597 and 598;
heavy chain CDR1-3 of SEQ ID NOS:
407, 408 and 409, and light chain CDR1-3 of SEQ ID NOS:
599, 600 and 601;
heavy chain CDR1-3 of SEQ ID NOS:
410, 411 and 412, and light chain CDR1-3 of SEQ ID NOS:
602, 603 and 604;
heavy chain CDR1-3 of SEQ ID NOS:
413, 414 and 415, and light chain CDR1-3 of SEQ ID NOS:
605, 606 and 607;
heavy chain CDR1-3 of SEQ ID NOS:
416, 417 and 418, and light chain CDR1-3 of SEQ ID NOS:
608, 609 and 610;
heavy chain CDR1-3 of SEQ ID NOS:
419, 420 and 421, and light chain CDR1-3 of SEQ ID NOS:
611, 612 and 613;
heavy chain CDR1-3 of SEQ ID NOS:
422, 423 and 424, and light chain CDR1-3 of SEQ ID NOS:
614, 615 and 616;
heavy chain CDR1-3 of SEQ ID NOS:
425, 426 and 427, and light chain CDR1-3 of SEQ ID NOS:
617, 618 and 619;
heavy chain CDR1-3 of SEQ ID NOS:
428, 429 and 430, and light chain CDR1-3 of SEQ ID NOS:
620, 621 and 622;
heavy chain CDR1-3 of SEQ ID NOS:
431, 432 and 433, and light chain CDR1-3 of SEQ ID NOS:
623, 624 and 625;
heavy chain CDR1-3 of SEQ ID NOS:
434, 435 and 436, and light chain CDR1-3 of SEQ ID NOS:
626, 627 and 628;
heavy chain CDR1-3 of SEQ ID NOS:
437, 438 and 439, and light chain CDR1-3 of SEQ ID NOS:
629, 630 and 631;
heavy chain CDR1-3 of SEQ ID NOS:
440, 441 and 442, and light chain CDR1-3 of SEQ ID NOS:
632, 633 and 634;
heavy chain CDR1-3 of SEQ ID NOS:
443, 444 and 445, and light chain CDR1-3 of SEQ ID NOS:
635, 636 and 637;
or heavy chain CDR1-3 of SEQ ID NOS:
446, 447 and 448, and light chain CDR1-3 of SEQ ID NOS:
638, 639 and 640.

188 more elements

Facts

Application

17/630,053Filed 24 Jul 2020 · us provisional application

Priority

26 Jul 2019

Published

US 2022/0289828 A115 Sep 2022

Granted

9 Sep 2025

Term ends

Not estimatedThe source records don’t support an estimate.

Classification19 codes

C07K 16/106
RNA viruses: picornaviridae , e.g. hepatitis A virus
A61K 39/42
Antibodies ; Immunoglobulins; Immune serum, e.g. antilymphocytic serum: viral
A61P 31/14
Antivirals: for RNA viruses
C07K 16/10
Against material from viruses: rNA viruses

Family

Application62/878,955Us provisional application · filed 26 Jul 2019

Application62/899,503Us provisional application · filed 12 Sep 2019

Application63/047,330Us provisional application · filed 2 Jul 2020

US 2022/0289828 A1Pre-grant publication · published 15 Sep 2022

US 12,410,241 B2This patent

From the US filing history. Foreign family members aren’t listed.