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US 12,410,224 B2Granted
IL-15-based fusions to IL-7 and IL-21
AssigneeAltor BioScience Corporation
InventorHing C Wong
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Abstract
The invention features multi-specific fusion protein complexes with one domain comprising IL-15 or a functional variant and a binding domain specific to IL-7 or IL-21.
Claims8
A soluble fusion protein complex comprising:
- a first fusion protein comprising interleukin-21 (IL-21) (SEQ ID NO:
- 6) and interleukin-15 receptor alpha sushi-binding domain/Fc (IL-15RαSu/Fc) (SEQ ID NO:8);
- and a second fusion protein comprising interleukin-7 (IL-7) (SEQ ID NO:10) and an IL-15 variant comprising an N72D mutation (IL-15N72D) (SEQ ID NO:12) or human wild-type IL-15, wherein the first and second fusion proteins are non-covalently linked to form the soluble fusion protein complex.
Dependencies are inferred from the claim text.