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US 12,410,216 B2Granted
Mutated glycoprotein of vesicular stomatitis virus
AssigneesCentre National de la Recherche Scientifique (CNRS), Universite Paris-Saclay
InventorsAurélie Albertini, Yves Gaudin, Hélène Raux, Laura Belot, Jovan Nikolic
Life of this patent
Estimating the term…
Abstract
The invention relates to an isolated non-naturally occurring protein comprising the amino acid sequence as set forth in SEQ ID NO: 1, and wherein the amino acid in position 8, 47, 209 and/or 354 is substituted by any amino acid different from the amino acid indicated at that position in said sequence SEQ ID NO: 1.
Claims30
A polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth in SEQ ID NO:
- 1, wherein the polypeptide comprises an amino acid mutation at position 47 and/or an amino acid mutation at position 354, and wherein the polypeptide retains the ability to induce membrane fusion and does not interact with LDL membrane receptor.
Dependencies are inferred from the claim text.