Cyclic compound having selective KRAS inhibitory effect on HRAS and NRAS
AssigneeChugai Seiyaku Kabushiki Kaisha
InventorsHatsuo Kawada, Koji Takano, Tomoya Kotake, Mirai Kage, Satoshi Hashimoto, Minoru Tamiya, Yuma Wakamiya, Ryuji Hayashi, Yuya Morita
Life of this patent
Estimating the term…
Abstract
Cyclic compounds that selectively inhibit KRAS were found. Moreover, cyclic compounds were found to interact with an amino acid residue specific to KRAS.
Claims24
A compound, which is (1S,4S,10S,13S,17S,20S,26S,28R,32S,38S,42Z)-20-cyclopentyl-28-ethoxy-32-[2-[3-methoxy-4-(trifluoromethyl)phenyl]ethyl]-N,N,2,14,18,21,24,36-octamethyl-10-[(1S)-1-methylpropyl]-3,9,12,15,19,22,25,31,34,37,45-undecaoxo-13-propyl-38-[[4-(trifluoromethyl)phenyl]methyl]spiro[2,8,11,14,18,21,24,30,33,36,39-undecazatetracyclo [37.5.1.04,8.026,30] pentatetracont-42-ene-23,l′-cyclobutane]-17-carboxamide.
A solvate of (1S,4S,10S,13S,17S,20S,26S,28R,32S,38S,42Z)-20-cyclopentyl-28-ethoxy-32-[2-[3-methoxy-4-(trifluoromethyl)phenyl]ethyl]-N,N,2,14,18,21,24,36-octamethyl-10-[(1S)-1-methylpropyl]-3,9,12,15,19,22,25,31,34,37,45-undecaoxo-13-propyl-38-[[4-(trifluoromethyl)phenyl]methyl]spiro[2,8,11,14,18,21,24,30,33,36,39-undecazatetracyclo [37.5.1.04,8.026,30] pentatetracont-42-ene-23,1′-cyclobutane]-17-carboxamide.
A salt of (1S,4S,10S,13S,17S,20S,26S,28R,32S,38S,42Z)-20-cyclopentyl-28-ethoxy-32-[2-[3-methoxy-4-(trifluoromethyl)phenyl]ethyl]-N,N,2,14,18,21,24,36-octamethyl-10-[(1S)-1-methylpropyl]-3,9,12,15,19,22,25,31,34,37,45-undecaoxo-13-propyl-38-[[4-(trifluoromethyl)phenyl]methyl]spiro[2,8,11,14,18,21,24,30,33,36,39-undecazatetracyclo [37.5.1.04,8.026,30] pentatetracont-42-ene-23,1′-cyclobutane]-17-carboxamide, or a solvate thereof.
Dependencies are inferred from the claim text.