Compounds targeting mutant calreticulin
AssigneeMYELOPRO DIAGNOSTICS AND RESEARCH GmbH
InventorsOleh Zagrijtschuk, Ruochen Jia
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Abstract
The present invention relates to compounds binding to calreticulin which selectively inhibit growth of CALR mutant cells and/or exhibit selective cytotoxicity towards CALR mutant cells, to pharmaceutical compositions comprising such compounds as well as to their use in treating diseases or conditions caused by or associated with a mutation of CALR, in particular myeloid malignancies, such as myeloproliferative neoplasms or myelodysplasia syndrome. The present invention also relates to screening assays allowing the identification of such compounds.
Claims1
A pharmaceutical composition comprising a compound and one or more pharmaceutically acceptable excipients, wherein the compound is selected from the group consisting of:
- and solvates, salts, complexes, polymorphs, crystalline forms, racemic mixtures, diastereomers, enantiomers, tautomers, isotopically labeled forms, and prodrugs thereof.
Dependencies are inferred from the claim text.