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US 12,410,177 B2Granted
Antimicrobial and anticancer cationic phthalocyanine compounds
AssigneeBMG (British Medical Group) Limited
InventorPaul Wight
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Abstract
Substituted phthalocyanines for the generation of singlet oxygen in which one or more of the substituents bear acationically charged N-alkylated pyridine.
Claims5
A population of compounds comprising compounds according to one or more of formulas Cs, C4h, D2h and C2v below:
- wherein in each of the above formulas:
- each occurrence of R is independently R′ or R″, where there is a mean average of (a) occurrences of R′ and (b) occurrences of R″ in each formula;
- and a+b=4;
- R′ is 3-oxygen linked pyridyl having the following structure:
- R″ is 3-oxygen linked N-alkylated pyridinium having the following structure:
- wherein the mean average total number of substituent R″ (b) is from 1 to 3.9;
- M is selected from aluminium or zinc;
- each formula has counterions X selected from Cl−, Br−, I−, methanesulphonate, ethanesulphonate, formate, acetate or other inorganic or organic counter-ion or mixture thereof;
- and
- wherein R′″ is optionally branched C1-C8 alkyl,
- and wherein the population of compounds comprises a compound having the following structure:
8 more elements
Dependencies are inferred from the claim text.