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US 12,410,161 B2Granted
Tetrahydrobenzo-quinoline sulfonamides derivative compounds
AssigneeUcb Biopharma Srl
InventorsTimothy John Norman, Oliver Philps, Gregory William Haslett, Jag Paul Heer, Giancarlo Trani
Life of this patent
Estimating the term…
Abstract
The present invention relates to tetrahydrobenzo-isoquinoline sulfonamides derivatives of formula (I), processes for preparing them, pharmaceutical compositions containing them and their use in treating disorders caused by IgE (such as allergic responses, non-allergic mast cell responses or certain autoimmune responses), and in particular disorders caused by the interaction of IgE with the FIERI receptor.
Claims18
A compound of formula (I) or a pharmaceutically acceptable salt thereof:
- Wherein
- X is C or N;
- Y is —(C═N)— or —(N═N)— or O or —(O—NH)—;
- R1 represents:
- Hydrogen;
- or
- Heteroaryl optionally substituted with one or more selected from the group consisting of amino;
- C(O)O-C1-6-alkyl;
- C(O)NH-C1-6-alkyl;
- NH-C1-6-alkyl;
- NH-C1-6-alkanediyl-C3-6-cycloalkyl;
- heteroaryl;
- NH-heteroaryl optionally substituted with one or more Ra;
- or
- NHC(NCN)NH-Aryl optionally substituted with one or more Ra;
- or
- NH-heteroaryl optionally substituted with one or more groups seleted from the group consisting of C1-6-alkyl and heteroaryl optionally substituted with one or more Ra;
- or
- C(O)NH-C1-6-alkyl;
- or
- C(O)NH-C1-6-alkanediyl-aryl optionally substituted with one or more Ra;
- or
- C(O)NH-C1-6-alkanediyl-heteroaryl optionally substituted with one or more Ra;
- or
- NHC(O)heteroaryl optionally substituted with one or more Ra;
- or
- NH-C3-8-cycloalkyl substituted with one or more C1-6-alkylamino;
- oxo or Ra;
- R2 represents:
- Hydrogen;
- or C(O)NH-C1-6-alkyl optionally substituted with aryl optionally substituted with one or more Ra;
- or
- Heteroaryl substituted with one or more group chosen amongst heteroaryl optionally substituted with one or more Ra;
- heteroarylamino optionally substituted with one or more Ra;
- or
- NH-Heteroaryl subtituted with a heteroaryl optionally substituted with one or more Ra;
- R3 represents:
- C1-6-alkyl optionally substituted with one or more R3a groups;
- C1-3-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R3a groups;
- C1-3-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
- C3-6-heterocycloalkyl optionally substituted with one or more R3a groups;
- or
- C3-6-cycloalkyl optionally substituted with one or more R3a groups;
- R3a represents hydrogen;
- halogen;
- C1-2-alkyl;
- hydroxy or C1-2-alkoxy;
- R4 represents:
- C3-6-cycloalkyl optionally substituted with one or more R4ª group;
- or C1-6-alkanediyl-C3-6-cycloalkyl optionally substituted with one or more R4ª group;
- or C1-6-alkanediyl-C3-6-heterocycloalkyl optionally substituted with one or more R4ª group;
- R4ª represents hydroxy;
- halogen;
- or C1-2-alkyl;
- and
- Ra represents halogen;
- nitrile;
- C1-6-alkyl;
- C1-6-haloalkyl;
- C1-6-alkoxy;
- C1-6-haloalkoxy;
- C(O)O-C1-6-alkyl or C(O)OH.
59 more elements
Dependencies are inferred from the claim text.