Substituted imidazole salt compounds, preparation method thereof, pharmaceutical composition thereof and application thereof
AssigneeXiamen Vivohealths Technology Co., Ltd.
InventorsXianming Deng, Shengcai Lin, Chensong Zhang
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Abstract
Disclosed in the invention are a type of compounds having aldolase selective inhibitory activity, a method for the preparation thereof, a pharmaceutical composition comprising the same, and use of these compounds in the manufacture of a medicament for inhibiting triglyceride and cholesterol synthesis, for reducing fatty acid synthesis, for preventing and/or treating obesity and type II diabetes, for preventing and/or treating tumor, for preventing and/or treating Parkinson's disease, for preventing and/or treating Alzheimer's disease or for prolonging the lifespan of mammals:
Claims10
A method of inhibiting aldolase activity, comprising contacting the compound having the general formula
- or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof or a pharmaceutical composition comprising the above compound with the aldolase:
- wherein
- R1 is C1-C22 alkyl;
- R2 is selected from the group consisting of H, methyl, ethyl, isopropyl, t-butyl, and cyclopropyl;
- R3 is selected from the group consisting of:
- 1) Formula (a),
- wherein any two of Z1, Z2, Z4, Z5 each are independently selected from the group consisting of:
- (1) H, F, Cl, Br, and cyano;
- and
- (2) C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluorine-containing alkyl, and C1-C3 fluorine-containing alkoxy;
- the rest and Z3 being H;
- Z6 is H or methyl;
- and
- 2) formula (b),
- wherein for Z1, Z2, Z3, Z4, and Z5:
- one is independently selected from the following groups:
- (1) H, F, Cl, Br, and cyano;
- (2) C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluorine-containing alkyl, and C1-C3 fluorine-containing alkoxy;
- the rest being H;
- Z6 is H or methyl;
- X− is an anion of a pharmaceutically acceptable inorganic or organic acid salt.
A method of inhibiting aldolase activity, comprising contacting a compound or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof or a pharmaceutical composition comprising the above compound, wherein the compound is selected from the group consisting of:
A method for inhibiting triglyceride synthesis, for treating obesity and type II diabetes, for treating fatty liver, for treating tumor, for treating Parkinson's disease, for treating Alzheimer's disease or for prolonging the lifespan of mammals, comprising administrating the compound having the general formula
- or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof;
- or a pharmaceutical composition comprising the above compound to the subject in need thereof:
- wherein
- R1 is C1-C22 alkyl;
- R2 is selected from the group consisting of H, methyl, ethyl, isopropyl, t-butyl, and cyclopropyl;
- R3 is selected from the group consisting of:
- formula (a),
- wherein any two of Z1, Z2, Z4, Z5 each are independently selected from the group consisting of:
- (1) H, F, Cl, Br, I, nitro, and cyano;
- and
- (2) C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluorine-containing alkyl, and C1-C3 fluorine-containing alkoxy;
- the rest and Z3 being H;
- Z6 is H or methyl;
- and
- 2) formula (b),
- wherein for Z1, Z2, Z3, Z4, and Z5:
- one is independently selected from the consisting of:
- (1) H, F, Cl, Br, I, nitro, and cyano;
- and
- (2) C1-C3 alkyl, C1-C3 alkoxy, C1-C3 fluorine-containing alkyl, and C1-C3 fluorine-containing alkoxy;
- the rest being H;
- Z6 is H or methyl;
- X− is an anion of a pharmaceutically acceptable inorganic or organic acid salt.
A method for inhibiting triglyceride synthesis, for treating obesity and type II diabetes, for treating fatty liver, for treating tumor, for treating Parkinson's disease, for treating Alzheimer's disease or for prolonging the lifespan of mammals, comprising administrating a compound or a stereoisomer thereof, a prodrug thereof, a pharmaceutically acceptable salt thereof or a pharmaceutically acceptable solvate thereof or a pharmaceutical composition comprising the above compound to the subject in need thereof:
- wherein the compound is selected from the group consisting of:
Dependencies are inferred from the claim text.