Fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof

A compound of Formula I:

• a prodrug thereof, a pharmaceutically acceptable salt thereof, or a pharmaceutically active metabolite thereof;
• wherein
• W is NH, N(CH3), or none, wherein when W is none R3 is directly attached to C(O) by a single bond;
• X is CH or N;
• Y is CH or N;
• Z is CH or N;
• wherein one of X, Y or Z is N;
• R1 is independently —C(O)OR4, —C(O)NHOH, —C(O)NHNH2, CF3, CHO, CN or heteroaryl;
• wherein R4 may be independently C1-C5 alkyl;
• R2 is independently hydrogen, halogen, hydroxy, alkyl, alkoxy, thioalkyl, haloalkoxy, cyano, N(CH3)2, wherein R2 may be linked via any position on the phenyl ring;
• R3 is independently C5-C20 alkyl, C3-C8 cycloalkyl, C4-C8 heterocycloalkyl, C5-12 fused heterocycloakyl, C6-12 spirocycloalkyl, or aryl, wherein R3 may be unsubstituted or substituted at a carbon ring member with halogen or alkyl group.