Pyridinyl morpholine compound, preparation method therefor, and application thereof
AssigneesShanghai Zhongze Therapeutics, Co. Ltd., Shanghai Institute of Pharmaceutical Industry
InventorsJianqi Li, Yangli Qi, Xiaowen Chen, Junwei Xu, Ruixiang Yuan, Qiang Pu
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Abstract
Disclosed in the present invention are a pyridinyl morpholine compound, a preparation method therefor, and an application thereof. The present invention provides a pyridinyl morpholine compound as represented by formula I, a pharmaceutically acceptable salt thereof or a hydrate of the pharmaceutically acceptable salt thereof. The compound can be used as an antagonist for one or more of D2, D3 or 5-HT2A, and is used for preparing a drug for treating schizophrenia.
Claims18
A pyridinyl morpholine compound represented by formula I, a pharmaceutically acceptable salt thereof, or a hydrate of the pharmaceutically acceptable salt thereof:
- wherein, R1 is
- R3 is C1-C3 alkyl, “C1-C3 alkyl substituted by one C1-C3 alkoxy”, C3-C6 cycloalkyl, phenyl, “5- to 6-membered heteroaryl with 1 to 2 heteroatoms selected from one or more of N, O and S”, “5- to 6-membered heterocycloalkyl with one heteroatom of N, and 0 or 1 heteroatom selected from N, O and S”, or, “5- to 6-membered heterocycloalkyl with one heteroatom of N, and 0 or 1 heteroatom selected from N, O and S” substituted by one C1-C3 alkyl;
- the heterocycloalkyl is connected to the carbonyl in R1 by N atom;
- R4 and R5 are independently hydrogen or C1-C3 alkyl;
- R2 is phenyl, “5- to 6-membered heteroaryl with 1 to 2 heteroatoms selected from one or more of N, O and S”, or, phenyl substituted by one or more R2-1;
- R2-1 is independently C1-C3 alkoxy or halogen.
Dependencies are inferred from the claim text.