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US 12,410,126 B2Granted
Process for making Siponimod and intermediate thereof
AssigneeSynthon BV
InventorsRolf Keltjens, Ondrej Hylse, Jiri Partl
Life of this patent
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Abstract
The presented invention relates to a process for preparation of compound of formula (I) or a salt or a solvate thereof (i.e.) siponimod. The invention also relates to intermediates used in the process and solid forms of these intermediates.
Claims15
A process for preparation of Siponimod of formula (I):
- or a salt thereof or a solvate thereof, the process comprising:
- a) Reacting compound of formula (II) with a compound of formula (III),
- wherein LG is a leaving group, R1 is OH or OProt, and Prot is hydroxyl protective group,
- to obtain compound of formula (IV),
- wherein R1 is OH or OProt, and Prot is hydroxyl protective group;
- b) Transforming the compound of formula (IV) into Siponimod or a salt thereof or a solvate thereof.
3 more elements
Dependencies are inferred from the claim text.