Compounds and use thereof in methods of treatment
AssigneeThe University of Queensland
InventorsMathias Francois, Johannes Zuegg, Jeroen Overman, Sreeman Kumar Mamidyala, Angela Aguslyarti Salim, Frank Roger Fontaine, Matthew Allister Cooper, Robert John Capon, Avril Alexis Barbara Robertson
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Abstract
Disclosed are compounds of a formula provided herein that show efficacy in the inhibition of SOX18 protein activity, and in particular with respect to the ability of SOX18 to bind DNA and/or particular protein partners. Further, methods of treating angiogenesis- and/or lymphangiogenesis-related diseases, disorders or conditions, such as cancer metastasis and vascular cancers, are provided herein.
Claims17
A method of treating a SOX7-, SOX17-, or SOX18-dependent cancer, comprising:
- administering to a subject whose cancer has been tested for SOX7, SOX17, or SOX18 dependency an effective amount of a compound of Formula I:
- wherein:
- R1 is selected from the group consisting of OH and OR6, wherein R6 is C1-4 alkyl;
- R2 is selected from the group consisting of H, COOR7, and C(O)NR8R9, wherein R7, R8, and R9 are independently selected from the group consisting of H and C1-4 alkyl;
- R3 is L-A, wherein L is a linker selected from the group consisting of C2-8 alkyl, C2-8 alkenyl, and C2-8 alkoxyalkyl, and A is an optionally substituted naphthyl;
- R4 is selected from the group consisting of H, OR10, halo, and C1-4 alkyl, wherein R10 is selected from the group consisting of H and C1-4 alkyl;
- and
- R5 is selected from the group consisting of H, OR11, halo, and C1-4 alkyl, wherein R11 is selected from the group consisting of H and C1-4 alkyl;
- or a pharmaceutically effective salt, solvate or prodrug thereof.
Dependencies are inferred from the claim text.