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US 12,409,440 B1Granted
Separation module
AssigneeSpf Technologies LLC
InventorsErik O. Blomquist, Gaston De Los Reyes
Life of this patent
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Abstract
Methods and devices are disclosed for a separation device. A separation device includes a plurality stacked modules and a distribution network including an inter-module LEVEL-1 distributor an intermediate LEVEL-2 distributor and a planar LEVEL-3 distributor. The distribution network enables streamline lengths which are approximately equal and induces uniform velocity fluid flow. These features provide a narrow residence time distribution providing improved chromatographic performance.
Claims26
A system comprising:
- a feed end plate, having a feed port;
- a plurality of fluidly connected modules stacked adjacent to the feed end plate and fluidly coupled to the feed port;
- an eluent end plate having an eluent port, disposed opposite the feed end plate with the plurality of fluidly connected modules disposed in between the feed end plate and the eluent end plate;
- wherein each one of the plurality of fluidly connected modules comprises:
- a chromatographic media bed having first and second planar surfaces;
- a distribution network comprising:
- an inter-module (LEVEL-1) distributor pair adjacent to the chromatographic media bed, a first one of the inter-module LEVEL-1 distributor pair having at least one passageway substantially perpendicular to the first and second planar surfaces and fluidly coupled to the feed port and a second one of the inter-module LEVEL-1 distributor pair having at least one different passageway substantially perpendicular to the first and second planar surfaces and fluidly coupled to the eluent port;
- an intermediate (LEVEL-2) distributor pair, a first one and a second one of the LEVEL-2 distributor pair disposed on opposite sides of the chromatographic media bed, having an array of passageways approximately parallel to the planar surfaces and fluidly coupled to a corresponding one of the inter-module LEVEL-1 distributor pair;
- and
- a planar (LEVEL-3) distributor pair, each of a first one and a second one of the planar LEVEL-3 distributor pair fluidly coupled to the respective first and second ones of the intermediate LEVEL-2 distributor pair and each one of the pair having an array of passageways parallel to the first and second planar surfaces, the first one of the pair in contact with the first surface of the chromatographic media bed and the second one of the pair in contact with the second surface of the chromatographic media bed.
7 more elements
A method comprising:
- providing a modular chromatographic system having a plurality of stacked modules, each stacked module including a chromatographic media bed having first and second planar surfaces and including a multilevel distribution network of each stacked module;
- distributing a feed stream to the chromatographic media bed, wherein a flow through the multilevel distribution network induces a plurality of streamlines having substantially equal lengths;
- inducing an isomikos flow through the multilevel distribution network;
- and
- collecting an eluent stream from the chromatographic media bed.
2 more elements
Dependencies are inferred from the claim text.