Cochleates made with soy phosphatidylserine
AssigneesRutgers, The State University of New Jersey, Matinas Biopharma Nanotechnologies, Inc.
InventorsRaphael Mannino, Ruying Lu
Life of this patent
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Abstract
Unpurified or low pure soy phosphatidylserine is used to make cochleates. The cochleates contain about 40-74% soy phosphatidylserine, a multivalent cation and a biological active. A preferred cochleate contains the antifungal agent amphotericin B.
Claims24
A method of treating a subject with a fungal infection comprising, administering to the subject a composition comprising a cochleate comprising (i) a soy-based phospholipid comprising about 40%-55% by weight soy phosphatidylserine, (ii) a multivalent cation, and (iii) an anti-fungal agent.
A method of treating a subject with a fungal infection comprising, administering to the subject a composition comprising a cochleate comprising (i) a soy-based phospholipid comprising a mixture comprising soy phosphatidylserine and phosphatidylcholine, (ii) a multivalent cation, and (iii) amphotericin B, wherein the soy-based phospholipid comprises about 40%-55% by weight soy phosphatidylserine.
Dependencies are inferred from the claim text.