Administering a lymphocytic choriomeningtitis virus (LCMV) with improved tumor regression properties
AssigneeAbalos Therapeutics GmbH
InventorsKarl Sebastian Lang, Halime Kalkavan
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Abstract
The invention relates to arenaviruses for use in the treatment and/or prevention of tumors and also a method for preparing arenaviruses with (improved) tumor-regressive properties.
Claims16
A method of treating a tumor comprising administering to a subject in need thereof a lymphocytic choriomeningitis virus (LCMV), wherein the sequences of the L-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile L-ribonucleic acid sequences, and the S-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile S-ribonucleic acid sequences.
A method of treating a tumor comprising administering to a subject in need thereof a lymphocytic choriomeningitis virus (LCMV), wherein the sequences of the L-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile L-ribonucleic acid sequences, the S-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile S-ribonucleic acid sequences, and the tumor is a solid tumor.
A method of treating a tumor comprising administering to a subject in need thereof a lymphocytic choriomeningitis virus (LCMV), wherein the sequences of the L-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile L-ribonucleic acid sequences, the S-ribonucleic acids of the LCMV are selected from the group consisting of WE, Clone 13 and Docile S-ribonucleic acid sequences, and the tumor is selected from the group consisting of oropharynx cancer, colon cancer, lung cancer, cervical cancer, liver cancer, melanoma, pharyngeal cancer, lymphoma, thyroid cancer, and bladder cancer.
Dependencies are inferred from the claim text.