Back to results
US 12,409,214 B2Granted
Immunogenic antigens
AssigneeLonghorn Vaccines and Diagnostics, LLC
InventorsJeffrey D. Fischer, Clara J. Sei, Luke T. Daum, Gerald W. Fischer
Life of this patent
Estimating the term…
Loading patent…
Loading patent…
AssigneeLonghorn Vaccines and Diagnostics, LLC
InventorsJeffrey D. Fischer, Clara J. Sei, Luke T. Daum, Gerald W. Fischer
Estimating the term…
The invention relates to composite antigens comprising an antigen obtained or derived from an antigenic epitope of one or more pathogens that induces an immune response in a mammal, an antigen obtained or derived from bacterial cell wall material that induces an immune response in a mammal such as LTA, PNG or LPS, and a T cell stimulating antigen such as CRM. Preferably the composite antigen comprises an immunogenic composition or a vaccine that is effective against the pathogen or can generate antibodies that can be collected that are protective against infection by the pathogen. In addition, the invention relates to vaccines comprising composite antigens and to method for treating and preventing an infection.
An immunogenic antigen comprised of:
An immunogenic antigen comprised of an epitope of peptidoglycan, alpha crystalline protein or heat shock protein of Mycobacteria, plus a mimotope of HA, NA, or M2e protein of Influenza virus, further comprising CRM as a T cell stimulating epitope and/or ALFQ as an adjuvant, wherein the contiguous peptide comprises the sequences of one or more of SEQ ID NOs. 1-20 and one or more of SEQ ID NOs. 25-28.
An immunogenic antigen comprised of an epitope of peptidoglycan, alpha crystalline protein or heat shock protein of Mycobacteria, plus a mimotope of an epitope of peptidoglycan, alpha crystalline protein or heat shock protein of Mycobacteria, further comprising CRM as a T cell stimulating epitope and/or ALFQ as an adjuvant, wherein the contiguous peptide comprises the sequences of one or more of SEQ ID NOs. 1-20 and one or more of SEQ ID NOs. 25-28.
An immunogenic antigen comprised of:
An immunogenic antigen comprised of:
Dependencies are inferred from the claim text.