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US 12,409,191 B2Granted
Renal cell populations and uses thereof
AssigneeProKidney
InventorsJoydeep Basu, Kelly Guthrie, Dominic Justewicz, Teresa Burnette, Andrew Bruce, Russell W. Kelley, John W. Ludlow
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Abstract
The present invention concerns enriched heterogeneous mammalian renal cell populations characterized by biomarkers, and methods of making and using the same.
Claims19
A method for preparing a formulation for treatment of kidney disease in a mammal comprising:
- characterizing a heterogeneous renal cell population prepared from a kidney sample of the mammal as suitable for implantation and/or eliciting a regenerative response, the characterizing comprising:
- (i) determining that cells of the population express gamma-glutamyl transpeptidase (GGT)-1;
- (ii) determining that cells of the population express a cytokine cytokeratin (CK);
- and
- (iii) determining that cells of the population secrete vascular endothelial growth factor (VEGF) and kidney injury molecule (KIM)-1;
- and
- formulating the heterogeneous renal cell population, characterized as suitable for implantation and/or eliciting the regenerative response, with a (i) biomaterial or (ii) pharmaceutically acceptable carrier or excipient.
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Dependencies are inferred from the claim text.