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US 12,409,183 B2Granted
Method of using iloprost for treating frostbite
AssigneeBTG International Limited
InventorsKevin A. Christal, Christa-Lynn J. Vampola, Wade W. Benton
Life of this patent
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Abstract
The present disclosure generally relates to treatment of frostbite by intravenous injection or intravenous infusion of iloprost or a pharmaceutically acceptable salt thereof.
Claims28
A method of treating severe frostbite in a subject, comprising
- a) diluting about 1 mL of a pre-dilution composition comprising a concentrated solution of iloprost, said concentrated solution of iloprost comprising (1) about 0.1 mg/mL of iloprost, or a pharmaceutically acceptable salt or a stereoisomer thereof, (ii) about 0.24 mg/mL of tromethamine, (iii) sodium chloride, and (iv) ethanol, in 0.9% sodium chloride, said diluted composition having a final concentration of about 1 μg/mL of iloprost, or a pharmaceutically acceptable salt or a stereoisomer thereof;
- and
- b) administering the diluted composition to the subject by intravenous infusion, wherein the administration comprises a titration step on a first day of administration, said titration step being repeated on the second and third days of administration;
- wherein the administration on the first day comprises a starting dose and increments by which the dose is increased to a maximum dose, and wherein the administration on the second and third days comprises the same starting dose and increments of increase as on the first day, but wherein the maximum dose achieved on each day may be different;
- wherein the diluted composition is administered to the subject for a maximum of 8 consecutive days;
- and
- wherein the method reduces the risk of digit amputation in the subject when compared with standard of care treatments for severe frostbite.
4 more elements
A method of treating severe frostbite in a subject, comprising
- a) diluting about 1 mL of a pre-dilution composition comprising a concentrated solution of iloprost, said concentrated solution of iloprost comprising (i) about 0.1 mg/mL of iloprost, or a pharmaceutically acceptable salt or a stercoisomer thereof, (ii) about 0.24 mg/mL of tromethamine, (iii) sodium chloride, and (iv) about 8.1 mg/mL of ethanol, in 0.9% sodium chloride, said diluted composition having a final concentration of about 1 μg/mL of iloprost, or a pharmaceutically acceptable salt or a stereoisomer thereof;
- and
- b) administering the diluted composition to the subject by intravenous infusion, wherein the administration comprises a titration step on a first day of administration, said titration step being repeated on the second and third days of administration;
- wherein the administration on the first day comprises a starting dose and increments by which the dose is increased to a maximum dose, and wherein the administration on the second and third days comprises the same starting dose and increments of increase as on the first day, but wherein the maximum dose achieved on each day may be different
- wherein the diluted composition is administered to the subject for a maximum of 8 consecutive days;
- and
- wherein the method reduces the risk of digit amputation in the subject when compared with standard of care treatments for severe frostbite.
4 more elements
A method of treating severe frostbite in a subject comprising
- a) diluting about 1 mL of a pre-dilution composition comprising a concentrated solution of iloprost, said concentrated solution of iloprost comprising (i) about 0.1 mg/mL of iloprost, or a pharmaceutically acceptable salt or a stereoisomer thereof, (ii) about 0.24 mg/mL of tromethamine, (iii) sodium chloride, and (iv) about 8.1 mg/mL of ethanol, in 0.9% sodium chloride, said diluted composition having a final concentration of about 1 μg/mL of iloprost, or a pharmaceutically acceptable salt or a stereoisomer thereof, wherein the composition has a pH of 8.3;
- and
- b) administering the diluted composition to the subject by intravenous infusion, wherein the administration comprises a titration step on a first day of administration, said titration step being repeated on the second and third days of administration;
- wherein the administration on the first day comprises a starting dose and increments by which the dose is increased to a maximum dose, and wherein the administration on the second and third days comprises the same starting dose and increments of increase as on the first day, but wherein the maximum dose achieved on each day may be different;
- wherein the diluted composition is administered to the subject for a maximum of 8 consecutive days;
- and
- wherein the method reduces the risk of digit amputation in the subject when compared with standard of care treatments for severe frostbite.
4 more elements
Dependencies are inferred from the claim text.