Ready to use LET formulations

A ready-to-use pharmaceutical formulation, consisting of:

• a) lidocaine hydrochloride in an amount of 40 mg/mL;
• b) epinephrine hydrochloride in an amount of 0.61 mg/mL;
• c) tetracaine hydrochloride in an amount of 5 mg/mL;
• d) propylene glycol in an amount of 10 mg/mL;
• e) sodium metabisulfite in an amount of 0.265 mg/mL;
• f) a disodium salt of ethylenediaminetetraacetic acid dihydrate (Na2EDTA DH) in an amount of 0.2 mg/mL;
• g) methylparaben in an amount of 1.8 mg/mL;
• h) hydroxyethylcellulose in an amount of 0 mg/mL, 17.6 mg/mL, or 35.2 ma/mL;
• and
• i) a sufficient amount of sterile water for injection;
• wherein the ready-to-use pharmaceutical formulation has a pH of from 3.6 to 3.9;
• and
• wherein the ready-to-use pharmaceutical formulation has epinephrine hydrochloride content of 90% to 115% of the epinephrine hydrochloride content of 0.61 mg/mL after storage at a temperature ranging from 22° C. to 25° C. for 380 days.