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US 12,409,147 B2Granted
Thrombolytic and neuro/vasculoprotective nanoconjugates
AssigneeThe Cleveland Clinic Foundation
InventorVinod Labhasetwar
Life of this patent
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Abstract
Provided herein are compositions, systems, kits, and methods for treating a patient with a thromboembolism by administering nanoconjugates comprising nanoparticles encapsulating and/or conjugated to: i) tissue-type plasminogen activator (tPA), and ii) at least one antioxidant enzyme selected from the group consisting of: superoxide dismutase, glutathione peroxidase, glutathione reductase, and a catalase.
Claims3
A method of treating a patient with a stroke comprising:
- intravenously administering a composition to a subject who has had a stroke, wherein said intravenously administering occurs more than 4.5 hours after said stroke,
- wherein said composition comprises nanoparticles encapsulating tissue-type plasminogen activator (tPA), superoxide dismutase, and a catalase, and
- wherein said nanoparticles have pores and comprise PLGA and PVA.
Dependencies are inferred from the claim text.