System, method, and composition for skin improvement and transient flora reduction

A method for preparing a moisturizing hand sanitizer composition, the method comprising:

• a) preparing a first hydrophobe-in-water dispersion by:
• i) low energy mechanical processing to obtain a homogenous mixture comprising:
• water, a humectant, and one or more hydrophobes;
• wherein the low energy mechanical processing comprises mechanical mixing at ambient temperature and ambient pressure, until an average particle size of the one or more hydrophobes in the mixture is less than 150 microns, to yield an outflow;
• the mixture having 10% by wt. of the mixture or less of amphiphiles and amphiphilic compounds having a Critical Micelle Concentration (CMC) less than or equal to 10−8 mol/L, and
• ii) subjecting the outflow to high-pressure high-shear processing to form the first, hydrophobe-in-water dispersion, wherein the high-pressure high-shear processing comprises mixing at a temperature from about 15° to about 30° C., a pressure from about 6000 psi to about 31,000 psi, and a shear comprising unaligned shear forces that push a portion of a particle body in the outflow in one specific direction, and another portion of the particle body in the outflow in an opposite direction, causing particles in the outflow to fracture and be broken into smaller particles until at least 79 wt. % of the total particles in the dispersion are ±1.50 standard deviations of an average particle size of the dispersion, the average particle size of the dispersion being from about 150 nm to about 480 nm;
• b) preparing an aqueous solvent fluid by combining and mixing water, ethanol or isopropanol, and a humectant;
• and
• c) combining the at least first hydrophobe-in-water dispersion and the aqueous solvent fluid to form the composition, wherein the ethanol or isopropanol in the composition is in an amount from 60% v/v to 95% v/v of the composition;
• wherein stability of the combined first hydrophobe-in-water dispersion and aqueous solvent fluid is enhanced when the average particle size of the one or more hydrophobes in the outflow from low energy mechanical processing is less than 150 microns.