Methods of detecting septic arthritis, transient synovitis and osteomyelitis
AssigneeWashington University
InventorScott Luhmann
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Abstract
The present disclosure provides methods for detecting septic arthritis, transient synovitis, or osteomyelitis, based on protein signatures. Specifically, the method comprising: (i) measuring expression levels of one or more proteins in a biological sample obtained from the subject; (ii) determining a protein signature correlated with a detected disease based on the expression levels of the proteins in step (i); and (iii) assessing the occurrence or severity of the subject correlated with the disease based on the protein signature determined in step (ii). The methods may further comprise identifying suitable treatment for the patient based on the protein signatures.
Claims7
A method of identifying and treating a subject having septic arthritis, the method comprising:
- i) measuring expression levels of proteins comprising TGFα, IL-7, IL-33 and IL-28A in a blood sample obtained from the subject;
- ii) determining a septic arthritis protein signature based on the expression levels of the proteins in step (i);
- and
- iii) assessing septic arthritis occurrence or severity of the subject based on the protein signature determined in step (ii);
- and
- iv) administering a therapeutically effective amount of a therapeutic agent to the subject based on the septic arthritis occurrence or severity determined in step (iii), wherein the therapeutic agent is selected from the group consisting of an antibiotic, an antiviral agent, and an anti-inflammatory agent.
Dependencies are inferred from the claim text.