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US 12,404,535 B2Granted
NAD(P) depot for NAD(P)-dependent enzyme-based sensors
AssigneeAbbott Diabetes Care Inc.
InventorsTianmei Ouyang, Cade Fox, Zenghe Liu, Stephen Oja, Benjamin J. Feldman
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Abstract
The present disclosure provides analyte sensors including one or more NAD(P)-dependent enzymes and an internal supply of NAD(P) for the detection of an analyte. The present disclosure further provides methods of using such analyte sensors for detecting one or more analytes present in a biological sample of a subject, and methods of manufacturing said analyte sensors.
Claims18
An analyte sensor comprising:
- (i) an internal supply of NAD(P);
- (ii) a permeable polymer that overcoats the internal supply of NAD(P);
- (iii) a first working electrode that is disposed upon the active surface of the permeable polymer, wherein the first working electrode is a permeable working electrode;
- (iv) an analyte-responsive active area disposed upon a surface of the first working electrode, wherein the analyte-responsive area comprises an NAD(P)-dependent enzyme;
- and
- (v) a mass transport limiting membrane that overcoats the analyte-responsive area, wherein the membrane is permeable to the analyte.
3 more elements
Dependencies are inferred from the claim text.