Uses and methods for oncolytic virus targeting of IL-4/IL-13 and fusions thereof
AssigneeMedicenna Therapeutics Inc.
InventorFahar Merchant
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Abstract
The present invention provides an oncolytic virus vector containing a sequence encoding IL-4 receptor targeted cargo protein, including IL-4 muteins and/or IL-13 muteins, the oncolytic virus encoded therefrom, the uses of the oncolytic virus for treating cancer.
Claims11
A modified oncolytic virus vector comprising at least one nucleic acid sequence encoding an IL-4 receptor targeted cargo protein and an IL-2 mutein, wherein the oncolytic virus vector is a modified adenovirus vector.
A modified oncolytic adenovirus vector comprising (i) an adenovirus genome, wherein optionally the nucleotides encoding amino acids 122-129 of E1A polypeptide are deleted, and (ii) at least one nucleic acid sequence encoding an IL-4 receptor targeted cargo protein and an IL-2 mutein.
Dependencies are inferred from the claim text.