Degradable multi-arm polyethylene glycol derivative
AssigneesNof Corporation, Tokyo Institute of Technology
InventorsHiroki Yoshioka, Ken Hamura, Kazuki Osakama, Nobuhiro Nishiyama
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Abstract
A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.
Claims15
A degradable polyethylene glycol derivative represented by the following formula (1):
- wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.
A degradable polyethylene glycol derivative represented by the following formula (2):
- wherein n3 and n4 are each independently 110-950, W3 and W4 are each independently an oligopeptide of 2-5 residues, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.
A degradable polyethylene glycol derivative represented by the following formula (3):
- wherein n1 and n2 are each independently 45-950, W5 and We are each independently an oligopeptide consisting of 5 to 47 residues and having a symmetrical structure centered on glutamic acid, b1 and b2 are each independently 2-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, X1 and X2 are each independently a functional group capable of reacting with a bio-related substance, and L1, L2, L3, L4, L5 and L6 are each independently a divalent spacer.
A degradable polyethylene glycol derivative-bonded bio-related substance represented by the following formula (4):
- wherein n1 and n2 are each independently 45-950, W1 and W2 are each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom or a nitrogen atom, D1 and D2 are each independently a bio-related substance, and L3, L4, L5, L6, L11 and L12 are each independently a divalent spacer.
Dependencies are inferred from the claim text.