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US 12,404,332 B2Granted
Methods for diagnosing and treating cancers
AssigneeResearch Development Foundation
InventorsTyler J. Curiel, Anand Kornepati
Life of this patent
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Abstract
Provided herein are methods for the diagnosis, assessment, and treatment of cancer. In some aspects, detection of intracellular or cytoplasmic PD-L1, or measuring the ratio of cytoplasmic to surface PD-L1, can be used to identify cancers that may respond to immunotherapies or a DDR inhibitor such as, e.g., a Chk1 inhibitor, a PARP inhibitor, an ATM inhibitor, or an ATR inhibitor.
Claims48
A method of treating a melanoma, bladder, breast or ovarian cancer in a human subject, comprising measuring in cells of the melanoma, bladder, breast or ovarian cancer the expression of
- i) cytoplasmic or intracellular PD-L1 and/or
- ii) one or more Lamtor proteins;
- and
- administering an anti-cancer therapy to the subject having the melanoma, bladder, breast or ovarian cancer, wherein the cancer expresses cytoplasmic or intracellular PD-L1 and/or one or more LAMTOR proteins at a decreased level as compared to such expression in control cells;
- wherein:
- i) when the cancer is melanoma the control cells are B16 cells;
- ii) when the cancer is bladder cancer the control cells are RT4 cells;
- iii) when the cancer is breast cancer control cells are 4TI cells;
- and
- iv) when the cancer is ovarian cancer and wherein the control cells are ES2 cells.
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Dependencies are inferred from the claim text.