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US 12,404,312 B2Granted
Engineered VEGF variants for retinal neuroprotection, promotion of axon growth and axon regeneration
AssigneeMassachusetts Eye and Ear Infirmary
InventorsYin Shan Eric Ng, Junhui Shen
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Abstract
The invention provides methods of promoting retinal ganglion axon formation, survival, and synapse formation.
Claims17
An engineered vascular endothelial growth factor (VEGF) chimeric polypeptide comprising:
- a first VEGF polypeptide covalently linked to a second VEGF polypeptide via a first polypeptide linker comprising the amino acid sequence of SEQ ID NO:
- 14, and a second polypeptide linker comprising the amino acid sequence of SEQ ID NO:
- 15 linking the second VEGF polypeptide to a flexible transmembrane anchor.
An engineered vascular endothelial growth factor (VEGF) chimeric polypeptide comprising:
- a sequence identity that is at least 80% identical to SEQ ID NO:
- 1 over the entire length of SEQ ID NO:
- 1.
A retinal ganglion cell (RGC) comprising a membrane anchored vascular endothelial growth factor (VEGF) chimeric polypeptide, wherein said chimeric VEGF polypeptide comprises SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.