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US 12,404,305 B2Granted
Chimeric polypeptides and uses thereof
AssigneeKite Pharma, Inc.
InventorsStuart A. Sievers, Jed J. W. Wiltzius
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Abstract
The invention provides novel peptides (e.g., linkers) and polypeptide compositions comprising the linkers (e.g., fusion proteins) and methods of using the polypeptide compositions. Peptides (e.g., linkers) are useful as tags and for engineering fusion proteins (e.g., antigen binding molecules, scFv). Polypeptide linkers described herein facilitate flexibility of linked peptides allowing for proper folding, conformation and reduced immunogenicity.
Claims4
A fusion protein comprising:
- a first polypeptide and a second polypeptide covalently linked by a peptide comprising the amino acid sequence selected from the group consisting of:
- (i) GGGSGKPGSGEGGGS (SEQ ID NO:
- 7);
- (ii) GGGSGKPGSGEGGGGS (SEQ ID NO:
- 8);
- (iii) GGGGSGKPGSGGGGS (SEQ ID NO:
- 9);
- (iv) GGGGSGKPGSGEGGS (SEQ ID NO:
- 10)
- (v) GGGGSGKPGSGEGGGS (SEQ ID NO:
- 11);
- and
- (vi) GGGGSGKPGSGEGGGGS (SEQ ID NO:
- 12).
11 more elements
Dependencies are inferred from the claim text.