Back to results
US 12,404,284 B2Granted
Spirocyclic inhibitors of hepatitis B virus
AssigneesOspedale San Raffaele S.R.L., Istituto Nazionale Genetica Molecolare - Ingm
InventorsRomano Di Fabio, Vincenzo Summa, Leda Ivanova Bencheva, Raffaele De Francesco, Lorena Donnici, Luca Guidotti, Matteo Iannacone, Adolfo Prandi, Marilenia De Matteo, Pietro Randazzo
Life of this patent
Estimating the term…
Abstract
The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.
Claims17
A compound of general formula (I):
- wherein:
- Cy is aryl or heteroaryl;
- each of m and n is independently 1 or 2;
- R1 is H, F, Br, Cl or CH3;
- R2 is selected from the group consisting of:
- 5 or 6 membered heteroaryl ring optionally substituted with one or more substituents each independently selected from the group consisting of:
- OH, halogen, CN, C1-6alkyl, hydroxyC1-6alkyl, haloC1-6alkyl, haloC1-6alkoxy, C1-6alkoxy and NH2;
- haloC1-4alkyl;
- and
- C(═O)NR3R4;
- each of R3 and R4 is independently selected from the group consisting of:
- hydrogen;
- C1-3alkyl;
- haloC1-4alkyl;
- and
- C3-5-cycloalkyl optionally substituted with one or more substituents each independently selected from the group consisting of:
- methyl, F, Cl, CHF2 and CF3;
- or R3 and R4 form together with the nitrogen atom to which they are attached a cyclic amine selected from the group consisting of:
- aziridine, azetidine, pyrrolidine, piperidine, morpholine and thiomorpholine each of said cyclic amine being optionally substituted with one or more substituents each independently selected from the group consisting of:
- methyl, fluorine, CHF2 and CF3;
- Ra, Rb, Rc and Rd are each independently selected from the group consisting of:
- hydrogen, halogen, methyl, CN, CHF2 and CF3;
- or a pharmaceutically acceptable salt, solvate or stereoisomer thereof.
20 more elements
Dependencies are inferred from the claim text.