2,4,6-trisubstituted 1,3,5-triazines as modulators of CX3CR1
OwnerKarolina Nilsson, Martin Bauer +3inventors
InventorsKarolina Nilsson, Martin Bauer, Maria Olwegard Halvarsson, Mikael Brink, Fredrik Bergström
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Abstract
There are disclosed certain 2,4,6-trisubstituted 1,3,5-triazine compounds of Formula (I), and pharmaceutically acceptable salts thereof, together with compositions containing them and their use in therapy. The compounds are modulators of CX3CR1 and are thereby particularly useful in the treatment or prophylaxis of cardiovascular disorders such as non-ischemic dilated cardiomyopathy and heart failure.
Claims30
A compound selected from N-(4-((R)-2-(2,3-Difluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-((S)-2-(2,3-Difluorophenyl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide:
- or a pharmaceutically acceptable salt thereof.
A compound selected from N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-((R)-2-(6-methoxypyridin-3yl)propyl)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-(((R)-1-Hydroxy-4-methylpentan-2-yl)amino)-6-((S)-2-(6-methoxypyridin-3yl)propyl)-1,3,5-triazin-2-yl)methanesulfonamide:
- or a pharmaceutically acceptable salt thereof.
A compound selected from N-(4-((R)-2-(5-Fluoro-6-methoxypyridin-3-yl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide and N-(4-((S)-2-(5-Fluoro-6-methoxypyridin-3-yl)propyl)-6-(((R)-1-hydroxy-4-methylpentan-2-yl)amino)-1,3,5-triazin-2-yl)methanesulfonamide:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.