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US 12,404,243 B2Granted
Inhibitors of the Wnt/beta-catenin pathway
AssigneeThe Regents of the University of California
InventorsMichael E. Jung, Xiaohong Chen, Cun-Yu Wang, Jiong Li, Jie Zheng
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to compounds that are capable of modulating the WNT/Beta-Catenin pathway. The disclosure further relates to methods of treating colorectal cancer and other WNT/Beta-Catenin mediated cancers.
Claims16
A compound having a structure represented by Formula Ib or a pharmaceutically acceptable salt thereof:
- wherein
- R4 is substituted alkenyl, substituted acyl, substituted C(O)alkyl, substituted C(O)Oalkyl, substituted C(O)Oaryl, substituted C(O)Oheteroaryl, substituted C(O)N(R5aR5b), or substituted alkylsulfonyl, further wherein each substituted alkenyl, substituted acyl, substituted C(O)alkyl, substituted C(O)Oalkyl, substituted C(O)Oaryl, substituted C(O)Oheteroaryl, substituted C(O)N(R5aR5b), or substituted alkylsulfonyl is substituted with at least one basic nitrogen;
- and
- R5a and R5b are each independently hydrogen, alkyl, or aryl.
1 more element
A compound selected from:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.