Non-peptidic cell-penetrating motifs

A compound having a structure according to Formula I or II

• or pharmaceutically acceptable salt thereof,
• wherein:
• A is a non-peptidic multivalent moiety, wherein A is selected from the group consisting of:
• (a) a carbocyclyl;
• (b) a heterocyclyl;
• (c) an aryl;
• (d) a heteroaryl;
• and
• (e) a sugar alcohol;
• each L is independently a bond, or an alkylene, alkenylene, alkynylene, carbocyclyl, heterocyclyl, or —Rc—X1—Rd—, wherein Rc and Rd are independently selected from alkylene, alkenylene, alkynylene, carbocyclyl, or heterocarbocyclyl, each of which are optionally substituted, and X1 is O, NH, or S;
• each M is independently a bond, or an alkylene, alkenylene, alkynylene, carbocyclyl, heterocyclyl, or —Re—X2—Rf—, wherein Re and Rf are independently selected from alkylene, alkenylene, alkynylene, carbocyclyl, or heterocarbocyclyl, each of which are optionally substituted, and X2 is O, NH, or S;
• each X is independently a first bonding group that links R1 to A, wherein X is a divalent group;
• each Y is a second bonding group that directly or indirectly links A to a guanidine group, wherein the guanidine group refers to the structure:
• each Z is a lone pair;
• each R1 is independently a hydrophobic amino acid residue, or analog thereof, having an aromatic side chain;
• each R2 is independently absent or a moiety comprising hydrophobic residue;
• each R3 is independently a cargo moiety;
• each p is independently 1 to 3;
• each q is independently 2 to 7;
• and
• each s is independently an integer from 1 to 3.