Preparation method for trans-cyclobutane-o-dicarboxylic acid ester and derivative thereof

Abstract

A preparation method for a trans-cyclobutane-o-dicarboxylic acid ester and a derivative thereof includes the following steps: in an organic solvent, catalyzing a substrate with a structure as shown in a structural formula I by using organic alkali at 50-90° C. so as to generate isomerization, acquiring the trans-cyclobutane-o-dicarboxylic acid ester or the derivative thereof, herein the structural formula I is as follows: Each R1, R2, R3 and R4 is independently one of hydrogen or an alkyl of C1-C5, and each of R5 and R6 is independently one of alkyl of C1-C10 and benzyl.

Dependencies are inferred from the claim text.