Methods of making bempedoic acid and compositions of the same

A pharmaceutical material comprising a crystalline form of the compound of formula (V):

• wherein the pharmaceutical material comprises the compound of formula (V) in an amount of from about 98% to about 102% by weight based on the total weight of the pharmaceutical material, as determined by a high performance liquid chromatography (HPLC) assay;
• and the pharmaceutical material comprises 0.0001% to 0.15% of a compound of formula (VIII):
• or a pharmaceutically acceptable salt thereof, based on the total weight of the pharmaceutical material.

A pharmaceutical material comprising a crystalline form of the compound of formula (V):

• or a pharmaceutically acceptable salt thereof;
• wherein the pharmaceutical material comprises the compound of formula (V), or a pharmaceutically acceptable salt thereof, in an amount greater than 85% by weight based on the total weight of the pharmaceutical material, and the pharmaceutical material comprises 0.0001% to 0.15% of a compound of formula (VIII):
• or a pharmaceutically acceptable salt thereof, based on the total weight of the pharmaceutical material.