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US 12,403,477 B2Granted
Method and device for creating organotypic lumen models in a microwell plate
AssigneeWisconsin Alumni Research Foundation
InventorsDavid J. Beebe, Patrick H. McMinn
Life of this patent
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Abstract
A method and device of creating a lumen model in a microwell plate defining a well is provided. A rod is inserted through the well of the microwell plate and the well is filled with a polymerizable material. The material is polymerized in the well. The rod is removed from the well of the microwell plate such that the polymerized material defines a lumen.
Claims11
A device for creating a lumen in a microenvironment, comprising:
- a microwell plate defining a plurality of wells arranged in rows and columns, each of the plurality of wells defined by at least one sidewall having first and second openings therein;
- a plurality of rods, each rod selectively moveable between a first position wherein each rod is removed from corresponding first and second openings in each of the at least one sidewall defining the plurality of wells and a second position wherein each rod is inserted through the corresponding first and second openings in each of the at least one sidewall defining the plurality of wells;
- and
- a fixture interconnected to the plurality of rods, the fixture configured for moving the plurality of rods between the first and second positions.
1 more element
Dependencies are inferred from the claim text.