Method and system for studying biological cells

A method of avidity-based cell screening and/or selection, comprising steps of:

• providing a sample holder comprising a holding space for holding a fluid medium;
• wherein the holding space is provided with a functionalized wall surface;
• providing a sample comprising cellular bodies in a fluid medium in the holding space;
• contacting the sample comprising the cellular bodies with the functionalized wall surface and allowing the cellular bodies to adhere to the functionalized wall surface;
• generating an acoustic wave in the holding space to exert a force on the cellular bodies of the sample in the holding space in a direction away from the functionalized wall surface, wherein the exerted force causes rupture of bonds of the cellular bodies adhered to the functionalized wall surface, and movement of the cellular bodies away from the functionalized wall surface;
• determining a relation between an adhesion of the cellular bodies to the functionalized wall surface and the force, including quantifying an adhesion strength between multiple individual ones of said cellular bodies and the functionalized wall surface in parallel.