US 12,403,453 B2 · Stationary phase medium for adsorption chromatography and manufacturing method thereof

Abstract

The invention relates to a stationary phase medium for adsorption chromatography, which is in form of porous particles suitable for being packed into a chromatographic column. The porous particles are made of cross-linked polymeric material and formed with interconnected macropores to constitute a porous network, through which a mobile phase fluid may flow in a convective manner. The porous particles are substantially free of diffusive pores and, thus, the mass transfer through the porous network is governed by convection alone. The porous particles are fabricated to have irregular granular configurations with rough outer surfaces, so that the convective flow between the porous particles will not be impeded during chromatography process.

Claims15

Dependent claims

A stationary phase medium for adsorption chromatography comprising:

a plurality of porous particles made of cross-linked polymeric material with a Feret diameter ranging from 25 μm to 500 μm and having a porosity ranging from 70% to 90%, each being formed with multiple spherical macropores having a diameter ranging from 3 μm to 10 μm, wherein the spherical macropores are interconnected with one another via connecting pores to constitute a porous network with an average diameter ranging from 0.2 μm to 6 μm;
and
wherein the porous particles are in form of irregular granules having a Feret aspect ratio distribution between 1.0 and 3.5 with a standard deviation ranging from 1.2 to 2.2.

Dependencies are inferred from the claim text.

Stationary phase medium for adsorption chromatography and manufacturing method thereof

Life of this patent

Stationary phase medium for adsorption chromatography and manufacturing method thereof

Life of this patent

Abstract

Claims15