Stationary phase for chromatography
AssigneeDaicel Corporation
InventorsKanji Nagai, Satoshi Shinkura
Life of this patent
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Abstract
Provided is a stationary phase for chromatography, the stationary phase being made of inorganic carrier particles to which is bonded a polymer having a hydrophilic group on repeating units of a main chain thereof, and being produced by a particular production method.
Claims16
A stationary phase for chromatography, comprising inorganic carrier particles to which is bonded a polymer having a hydrophilic group on repeating units of a main chain thereof,
- wherein the stationary phase has a structure represented by Formula (II):
- wherein in Formula (II), W′ is a single bond or an alkylene group of 1 to 10 carbon atoms which may have a branched chain;
- W″ is hydrogen or an alkyl group of 1 to 12 carbon atoms;
- X is an amide group, an ester group, an N-alkylamide group of 1 to 3 carbon atoms, an ether group, a sulfoxide group, a sulfone group, a sulfide group, or a phosphate ester group;
- Y is an alkylene group of 1 to 30 carbon atoms;
- V is an ether group bonded to the inorganic carrier surface, an alkoxy group of 1 to 5 carbon atoms, halogen, alkylmercaptyl groups of 1 to 20 carbon atoms, nitrogen-containing groups, an allyl group, or a 2-methyl-2-propenyl group;
- Rt is hydrogen or an alkyl of 1 to 6 carbon atoms;
- R2 is a single bond or an alkylene of 1 to 12 carbon atoms;
- R3 is an alkylene of 1 to 6 carbon atoms;
- X2 is —O—, —NH—, or —N(CH3)—;
- Y2 is —PO4—, —N+H2—, —N+(R4)2—, or (—(CH2)a—O-)b, a is an integer of 1 to 5, and b is an integer of 1 to 20;
- Z2 is hydrogen, alkyl of 1 to 6 carbon atoms, halogen, —N+R34, —SO3—, —CO2—, or —PO4—R4;
- R4 is hydrogen, an alkyl of 1 to 6 carbon atoms, or a hydroxyalkyl of 1 to 6 carbon atoms;
- p is from 1 to 10;
- q is from 10 to 3000.
A stationary phase for chromatography, comprising inorganic carrier particles to which is bonded a polymer having a hydrophilic group on repeating units of a main chain thereof,
- wherein the stationary phase has a structure represented by Formula (V):
- in Formula (V), Y is a single bond or an alkylene group of 1 to 30 carbon atoms;
- V is an ether group bonded to the inorganic carrier surface, an alkoxy group of 1 to 5 carbon atoms, halogen, nitrogen-containing groups, an allyl group, an isopropenyl group, or an alkyl group of 1 to 5 carbon atoms;
- T′ is an alkylene residue of 1 to 12 carbon or a thioether;
- R1 is hydrogen or an alkyl of 1 to 6 carbon atoms;
- R2 is a single bond or an alkylene of 1 to 12 carbon atoms;
- R3 is an alkylene of 1 to 6 carbon atoms;
- X2 is —O—, —NH—, or —N(CH3)—;
- Y2 is, —PO4—, —N+H2—, —N+(R4)2—, or (—(CH2)a—O-)b, a is an integer of 1 to 5, and b is an integer of 1 to 20;
- Z2 is hydrogen, alkyl of 1 to 6 carbon atoms, halogen, —N+R34, —SO3—, —CO2—, or —PO4—R4;
- R4 is hydrogen, an alkyl of 1 to 6 carbon atoms, or a hydroxyalkyl of 1 to 6 carbon atoms;
- q is an integer of 2 to 300.
Dependencies are inferred from the claim text.