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US 12,403,293 B2Granted
Medical device for applying semi-permanent tattoo ink
AssigneeJason Candreva
InventorJason Candreva
Life of this patent
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Abstract
The disclosure relates to a medical device for applying a semi-permanent tattoo ink to mark patients for medical procedures, including but not limited to radiation therapy in the treatment of various types of cancer. The tattoo ink is removable or disappears over a period of time following intradermal application.
Claims8
A sterile, single-use tattoo device comprising:
- i) a hypodermic safety needle, and
- ii) an ampoule made of plastic containing a semi-permanent, disappearing tattoo ink and a breakable membrane which allows ink to flow at the time of tattoo application;
- wherein the semi-permanent, disappearing tattoo ink only remains visible to the naked eye for between 4 weeks and 18 months after it is tattooed on a patient's skin, is removed by the patient's immune system after it is tattooed on a patient's skin wherein the patient's immune system begins removing the semi-permanent, disappearing tattoo ink between 2 and 6 weeks after it is tattooed on a patient's skin, and wherein the semi-permanent, disappearing tattoo ink comprises:
- a) particles, wherein the particles comprise:
- i) a shell comprising bioabsorbable and biodegradable polymer;
- and
- ii) a core comprising:
- I) bioabsorbable and biodegradable polymers or a hydrogel matrix and a coloring agent having a molecular weight between 5 and 10×106 Daltons, wherein said coloring agent is intercalated, non-covalently, or covalently bound with the polymer or hydrogel matrix, and wherein the bioabsorbable and biodegradable polymer comprises a homopolymer, a copolymer, a diblock or triblock copolymer chosen from one or a combination of:
- polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, or aromatic polyanhydride;
- or
- II) a coloring agent having a molecular weight between about 5 and about 10×106 Daltons;
- wherein said coloring agent is encapsulated by the shell polymer wherein the shell bioabsorbable and biodegradable polymer comprises a first block or diblock polymer chosen from one or a combination of:
- polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, poly(sebacic anhydride) (poly(SA)), or aromatic polyanhydride;
- and
- b) a carrier solution.
12 more elements
A method for marking a patient for radiation therapy comprising a step of tattooing the patient with a semi-permanent, disappearing tattoo ink, wherein:
- i) the method comprises tattooing the patient only once with the semi-permanent, disappearing tattoo ink, and the semi-permanent, disappearing tattoo ink is removed from the patient's skin by the patient's immune system after it is tattooed on the patient's skin, wherein the patient's immune system removing the semi-permanent, disappearing tattoo ink between 2 and 6 weeks after it is tattooed on the patient's skin;
- ii) the semi-permanent tattoo ink remains visible to the naked eye for between 4 weeks and 18 months after it is tattooed on the patient's skin;
- iii) the semi-permanent tattoo ink comprises:
- a) particles, wherein the particles comprise:
- I) a shell comprising bioabsorbable and biodegradable polymer;
- and
- II) a core comprising:
- a) bioabsorbable and biodegradable polymers or a hydrogel matrix and a coloring agent having a molecular weight between 5 and 10×106 Daltons, wherein said coloring agent is intercalated, non-covalently, or covalently bound with the polymer or hydrogel matrix, and wherein the bioabsorbable and biodegradable polymer comprises a homopolymer, a copolymer, a diblock or triblock copolymer chosen from one or a combination of:
- polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, or aromatic polyanhydride;
- or
- b) comprising a coloring agent having a molecular weight between about 5 and about 10×106 Daltons;
- wherein said coloring agent is encapsulated by the shell polymer wherein the shell bioabsorbable and biodegradable polymer comprises a first block or diblock polymer chosen from one or a combination of:
- polycaprolectone (PCL), poly L-lactic acid (PLLA), poly(lactic-co-glycolic acid) (PLGA), polyethylene glycol (PEG), polyethylene glycol-diacrylate (PEGDA), polyorthoester, aliphatic polyanhydride, poly(sebacic anhydride) (poly(SA)), or aromatic polyanhydride;
- and
- b) a carrier solution.
12 more elements
Dependencies are inferred from the claim text.