Compositions and methods related to Rhamnus prinoides (gesho) extract for the inhibition of polymicrobial biofilm formation
AssigneeGeorgia State University Research Foundation, Inc.
InventorsMariya Campbell, Eric Gilbert
Life of this patent
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Abstract
Disclosed are compositions comprising Rhamnus prinoides (GESHO) extract or fragments thereof and methods of using Gesho extract for the inhibition of biofilm formation.
Claims23
A method of inhibiting biofilm formation on a surface comprising contacting a surface susceptible to biofilm formation with a composition consisting of 4-hydroxy-4-methylpentanone (HMP) and a pharmaceutically acceptable carrier or a composition consisting of a pharmaceutically acceptable carrier, HMP, and at least one small molecule selected from the group consisting of:
- an extract of Rhamnus prinoides (gesho), 4-ethoxy benzoic acid (4EB), ethyl 4-ethoxybenzoate (EEB), methyl gallate, methyl paraben, adipic acid, phytol, or phytol acetate;
- and wherein the biofilm is not caused by Staphylococcus aureus.
A method of enhancing the sensitivity of a biofilm to an antibiotic comprising contacting the biofilm with a composition consisting of 4-hydroxy-4-methylpentanone (HMP) and a pharmaceutically acceptable carrier.
A composition useful for biofilm inhibition, consisting of 4-hydroxy-4-methylpentanone (HMP) and a pharmaceutically acceptable carrier.
A method of inhibiting biofilm formation on a surface comprising contacting a surface susceptible to biofilm formation with a composition consisting of 4-hydroxy-4-methylpentanone (HMP) or a composition comprising HMP and at least one small molecule selected from the group consisting of:
- an extract of Rhamnus prinoides (gesho), 4-ethoxy benzoic acid (4EB), ethyl 4-ethoxybenzoate (EEB), methyl gallate, methyl paraben, adipic acid, phytol, or phytol acetate;
- wherein the biofilm is not caused by Staphylococcus aureus;
- and wherein the composition does not further include one or more active ingredients such as antimicrobial agents, anti-inflammatory agents, or anesthetics.
Dependencies are inferred from the claim text.