Cannabinoid derivatives as pharmaceutically active compounds and methods of preparation thereof
AssigneeJazz Pharmaceuticals Research UK Limited
InventorsAlan Silcock, Benjamin Whalley, Royston Gray, Hannah Straker, Karen Tse, Alexander Cobb, Laura Bryant
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Abstract
The present invention relates to a group of cannabinoid derivatives as pharmaceutically active compounds and methods of preparation thereof. The cannabinoid derivatives of the invention are analogues of cannabidiol (CBD). CBD is a non-psychoactive cannabinoid which has been used to treat various diseases and disorders. While such treatments hold promise, there remains a need in the art for more effective treatments and this has been brought about by way of the cannabinoid derivatives of the invention
Claims13
A compound of the general Formula I or a salt thereof
- where X is either CH2;
- O;
- NBoc;
- NFMoc;
- NZ;
- NTs;
- NAc;
- NC (O)iPr;
- NBz or NH and Y is either H or OH.
A compound of general Formula II or a salt thereof
- where X is either CH2;
- O;
- NBoc;
- NFMoc;
- NZ;
- NTs;
- NAc;
- NC (O) iPr;
- NBz or NH and Y is either H or OH.
A process for the production of a compound of general Formula I comprising reacting a resorcinol unit of Structure 1a-j via a Friedel-Crafts 1,4-addition to produce compounds of Structures 2a to 2j or 3a to 3j followed by subsequent steps to produce the compounds of general Formula I via intermediates.
A compound selected from any one of:
- wherein R1 is H, and
- wherein X is selected from any one of CH2, O, NBoc, NFmoc, NZ, NTs, NAc, NC(O)iPr and NBz.
A process for the production of a compound of general Formula II comprising reacting a resorcinol unit of Structure 1a-j via a Friedel-Crafts 1,4-addition to produce compounds of Structures 2a to 2j or 3a to 3j followed by subsequent steps to produce the compounds of general Formula II via intermediates.
Dependencies are inferred from the claim text.