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US 12,399,177 B2Granted
Combination treponemal and non-treponemal syphilis test
AssigneeBio-Rad Laboratories, Inc.
InventorsRavi Kaul, Weiming Zheng, Roger Walker
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Abstract
Provided herein are multiplex assays for detecting antibodies indicative of presence and stage of syphilis infection in an individual. Individuals infected with syphilis produce antibodies directed to syphilis components and the lipid cellular debris associated with the infection. The present disclosure represents the first combination of these diverse antibody targets in a single assay.
Claims14
A kit comprising:
- (i) a cardiolipin-lecithin-cholesterol antigen non-covalently attached to a solid support, wherein the cardiolipin-lecithin-cholesterol antigen is unmodified to reduce hydrophobicity;
- and
- (ii) a Treponema pallidum antigen attached to the solid support,
- and wherein the solid support is contained in a storage buffer that lacks ionic detergent.
1 more element
Dependencies are inferred from the claim text.