Spatial targeting of analytes

A method comprising:

• providing a substrate comprising a feature array, wherein the feature array comprises a plurality of features and analytes, intermediate agents, or a combination thereof that were previously captured by the plurality of features from a biological sample;
• arranging a feature capture block relative to the substrate such that a capture surface of the feature capture block faces the feature array on the substrate;
• identifying a region of interest on the feature array;
• emitting light toward a portion of the capture surface of the feature capture block that corresponds to the region of interest on the feature array to expose the portion of the capture surface to the light such that a light-activated adhesive on the portion of the capture surface is activated;
• permitting the light-activated adhesive on the portion of the capture surface exposed to the light to capture at least one feature of the plurality of features within the region of interest on the feature array, the at least one feature comprising at least one element of the analytes, the intermediate agents, or the combination thereof;
• removing the feature capture block from the substrate;
• and
• retrieving the at least one feature from the capture surface of the feature capture block.