Method and system for non-invasively monitoring product temperature in controlled lyophilization

A virtual thermocouple system for non-invasively predicting product characteristics in a lyophilization process, comprising:

• one or more temperature sensing systems each configured to be placed on an associated vial within a lyophilization chamber, the temperature sensing system, comprising:
• a resistive network, comprising:
• a temperature sensing device comprising a plurality of negative temperature coefficient (NTC) thermistors, and
• a load resistor coupled to a corresponding NTC thermistor thus generating a corresponding voltage divider circuit;
• a corresponding system-on-chip coupled to a corresponding resistive network and configured to i) power the corresponding resistive network, ii) receive corresponding signals from each NTC thermistor of the corresponding temperature sensing device, iii) process the signal associated with each NTC thermistor of the corresponding temperature sensing device and thus generate data associated with each NTC thermistor, and iv) transmitting the processed data;
• and
• a power generating device configured to provide power to the corresponding system-on-chip;
• and
• a base stations adapted to i) receive the processed data from a corresponding system-on-chip, and ii) using a predefined model, non-invasively translate the processed data to thermal characteristics of a corresponding product within the corresponding vial.