Antidote-mediated reversal of extracellular aptamer staining
AssigneeDuke University
InventorsBruce Sullenger, Bethany Gray, Michael Nichols
Life of this patent
Estimating the term…
Abstract
Provided herein are compositions and methods for sorting and/or identifying live cells. The compositions and methods provide for staining of live cells with aptamer so particular cells can be identified within or sorted from a heterogeneous population of live cells and subsequent reversal of the staining to prepare sorted and/or identified cells in their native state.
Claims9
An aptamer conjugate comprising a multiplicity of aptamers each comprising a binding label, wherein the binding label of each of the multiplicity of aptamers is complexed to a linker, the linker comprising a reporter label and/or a magnetic label.
Dependencies are inferred from the claim text.