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US 12,398,373 B2Granted
Enhanced immune effector cells and use thereof
AssigneeFate Therapeutics, Inc.
InventorsBahram Valamehr, Ryan Bjordahl, Jode Goodridge, Tom Tong Lee
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Abstract
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
Claims26
A cell or a population thereof, wherein
- (i) the cell comprises a polynucleotide encoding an IL15/IL15Rα fusion protein without an intracellular domain (IL15A);
- (ii) the fusion protein comprises a human IL 15 and a transmembrane domain;
- and
- (iii) the cell is a derivative NK cell obtained from differentiating a human induced pluripotent stem cell (iPSC), wherein the iPSC from which the derivative NK cell is differentiated comprises the polynucleotide.
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