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US 12,398,359 B2Granted
Cell culture device, cell culture method, and recording medium
AssigneesMitsubishi Electric Corporation, Keio University
InventorsOsamu Takahara, Kazuhide Kodeki, Akira Morikawa, Tetsushi Azuma, Kenjiro Takemura, Yuta Kurashina, Genichiro Fujii
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Abstract
An ultrasonic transducer (10) emits ultrasonic waves toward a culture solution (3) stored with cells (2) in a culture vessel (1). An acquirer acquires information indicating a settling state of the cells (2) in the culture solution (3). A controller controls an operation of the ultrasonic transducer (10) based on the information indicating the settling state of the cells (2).
Claims12
A cell culture device, comprising:
- an irradiator to emit ultrasonic waves toward a culture solution stored with cells in a culture vessel;
- and
- processing circuitry to
- detect the cells in the culture solution,
- acquire information indicating a settling state of the detected cells, and
- cause the irradiator to emit the ultrasonic waves when the cells are in the settling state based on the information indicating the settling state of the cells,
- wherein the information indicating the settling state of the cells includes a settling velocity calculated by dividing a settling distance determined from coordinates of a cell in two images captured at different times by an elapsed time between capture of the two images, and
- the processing circuitry compares the settling velocity to a threshold velocity and, when the settling velocity is higher than or equal to the threshold velocity, causes the irradiator to emit the ultrasonic waves.
5 more elements
Dependencies are inferred from the claim text.