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US 12,398,255 B2Granted
Biocompatible crosslinkers for controlled degradation of polymer hydrogels
AssigneeSaint Louis University
InventorSilviya Petrova Zustiak
Life of this patent
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Abstract
The present disclosure relates generally to hydrogel biomaterials. In particular, the present disclosure is directed to compositions and methods for developing hydrolytically degradable hydrogels.
Claims19
A hydrogel crosslinker of formula (I),
- wherein m is at least 10 repeating units;
- n1 and n2 ranges from 1 to 5 repeating units;
- X and Y are independently selected from CHR1, NR2, O, SR3, and aryl;
- R1 is selected from alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group;
- and R2, and R3 are independently selected from H, alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group.
2 more elements
A hydrolytically degradable hydrogel comprising a crosslinker of formula (I),
- wherein m is at least 10 repeating units;
- n1 and n2 ranges from 1 to 5 repeating units;
- X and Y are independently selected from CHR1, NR2, O, SR3, and aryl;
- R1 is selected from alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group;
- and R2, and R3 are independently selected from H, alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group;
- and a polymer.
3 more elements
A method of preparing a hydrolytically degradable hydrogel, the method comprising:
- providing a hydrogel precursor solution, the hydrogel precursor solution comprising a polymer;
- providing to the hydrogel precursor solution a crosslinker of formula (I),
- wherein m is at least 10 repeating units;
- n1 and n2 ranges from 1 to 5 repeating units;
- X and Y are independently selected from CHR1, NR2, O, SR3, and aryl;
- R1 is selected from alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group;
- and R2, and R3 are independently selected from H, alkyl, alkoxy, aryl, hydroxyl, amino, nitro, carboxyl, a halogen, a polar pendant group, and a non-polar pendant group;
- and
- allowing the hydrogel precursor solution and crosslinker to polymerize to form a hydrolytically degradable hydrogel.
6 more elements
Dependencies are inferred from the claim text.